Chloroquine concentration profile in the community of Mewat region, district Gurgaon (Haryana), India.

Simple item page
dc.contributor.authorDua, V Ken_US
dc.contributor.authorGupta, N Cen_US
dc.contributor.authorSharma, V Pen_US
dc.date.accessioned2009-05-27T16:25:22Z
dc.date.available2009-05-27T16:25:22Z
dc.date.issued1999-06-25en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractA survey was conducted to find chloroquine concentration profile in the community of Mewat region district Gurgaon (Haryana) of India. 88 P. falciparum and 3 P. vivax cases were detected out of 148 blood slides examined with a SPR of 61.48. Plasma chloroquine and desethylchloroquine concentrations were determined in 55 P. falciparum and 2 P. vivax patients and 29 persons whose blood slides were negative for malaria parasite before giving any treatment. Mean chloroquine concentrations in cases with P. falciparum parasites and without malaria parasites were 0.018 and 0.016 microg ml(-1) respectively. Chloroquine to desethyl chloroquine ratio was between 2 and 3 in both groups. Only 10 malaria parasite negative cases out of 29 had plasma chloroquine concentrations above 0.016 microg ml(-1) required for malaria chemoprophylaxis. Chloroquine was undetectable in plasma samples of 8 out of 55 P. falciparum cases. Chloroquine plasma concentrations in 21 P. falciparum cases were below therapeutically effective concentration of 0.016 microg ml(-1) suggesting improper treatment while in 29 P. falciparum cases, parasitemia recurred despite required chloroquine concentration confirming chloroquine resistant status. Irregular prophylaxis and lack of proper treatment was one of the major causes of malaria outbreak in this area.en_US
dc.description.affiliationMalaria Research Center, BHEL Ranipur, Hardwar, India.en_US
dc.identifier.citationDua VK, Gupta NC, Sharma VP. Chloroquine concentration profile in the community of Mewat region, district Gurgaon (Haryana), India. The Southeast Asian Journal of Tropical Medicine and Public Health. 1999 Jun; 30(2): 232-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/35173
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/1999-30-2/1999-30-2-232.pdfen_US
dc.subject.meshAdulten_US
dc.subject.meshAntimalarials --blooden_US
dc.subject.meshBody Weighten_US
dc.subject.meshChloroquine --analogs & derivativesen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMalaria, Falciparum --prevention & controlen_US
dc.subject.meshMalaria, Vivax --prevention & controlen_US
dc.titleChloroquine concentration profile in the community of Mewat region, district Gurgaon (Haryana), India.en_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
tsajtmph_1999v30n2p232.pdf
Size:
49.93 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Southeast Asian Journal of Tropical Medicine and Public Health