Effect of Antiretroviral Therapy on Neutrophil Oxidative Burst in Children

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dc.contributor.authorRehman, Nama Habib Uren_US
dc.contributor.authorGupta, Richaen_US
dc.contributor.authorDewan, Poojaen_US
dc.contributor.authorGomber, Sunilen_US
dc.contributor.authorGupta, Richaen_US
dc.contributor.authorRaizada, Alpanaen_US
dc.date.accessioned2023-08-19T04:53:38Z
dc.date.available2023-08-19T04:53:38Z
dc.date.issued2023-07
dc.description.abstractObjective To ascertain the efect of human immunodefciency virus (HIV) infection, as well as, antiretroviral therapy (ART) on neutrophil oxidative burst in children. Methods Fifty-fve children living with HIV infection (30 receiving ART for?2 y, 25 treatment-naïve) and 30 healthy controls, aged 18 mo–18 y, were assessed for hemogram and neutrophil oxidative burst. The treatment-naïve children were followed up and the above tests were repeated after 6 mo of ART. Results Mean (SD) serum MPO activity at 6 mo after ART [32.1 (±19.9) U/L] was comparable to that at disease onset [17.2 (±23.0) U/L], although it was signifcantly higher compared to that in children on ART?2 y [13.3 (±15.8) U/L] and controls [12.1 (±11.9) U/L]. Median fuorescence intensity (MFI) of unstimulated DHR was highest at 6 mo after ART and in the treatment-naïve group, which was signifcantly higher than in the controls, as well as, children receiving ART?2 y. Stimulation index was highest in the control group [442.4 (341.9–562.9)], which was comparable to that in children on ART?2 y [304.2 (153.2–664.8)], but was signifcantly higher than the treatment-naïve cohort [266.1 (148.2–339.4)] and children on ART for 6 mo [318.8 (154.9–395.6)]. Conclusion A hyperinfammatory state caused by an increased serum myeloperoxidase enzyme activity and increased basal neutrophil oxidative burst was seen in untreated HIV infection and during initial 6 mo of ART. ART given for?2 y normalized the impaired neutrophilic phagocytic functions.en_US
dc.identifier.affiliationsDepartment of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi 110095, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, Indiaen_US
dc.identifier.citationRehman Nama Habib Ur, Gupta Richa, Dewan Pooja, Gomber Sunil, Gupta Richa, Raizada Alpana. Effect of Antiretroviral Therapy on Neutrophil Oxidative Burst in Children. Indian Journal of Pediatrics. 2023 Jul; 90(7): 683–689en_US
dc.identifier.issn0973-7693
dc.identifier.issn0019-5456
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223759
dc.languageenen_US
dc.publisherDr. K C Chaudhuri Foundationen_US
dc.relation.issuenumber7en_US
dc.relation.volume90en_US
dc.source.urihttps://doi.org/10.1007/s12098-022-04321-xen_US
dc.subjectDihydrorhodamineen_US
dc.subjectInnateen_US
dc.subjectImmunityen_US
dc.subjectMyeloperoxidaseen_US
dc.titleEffect of Antiretroviral Therapy on Neutrophil Oxidative Burst in Childrenen_US
dc.typeJournal Articleen_US
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