Risk Factors of avascular Osteonecrosis of the Femoral Head in Children at the National ReferenceCenter for Sickle Cell Disease in Brazzaville, Congo

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dc.contributor.authorAtipo-Tsiba, F. O. Galibaen_US
dc.contributor.authorBilongo-Bouyou, A.en_US
dc.contributor.authorBango, J. C.en_US
dc.contributor.authorSamba, J. A. Eliraen_US
dc.contributor.authorGatsongui, B. M.en_US
dc.contributor.authorMalanda, F.en_US
dc.contributor.authorNgolet, L. O.en_US
dc.contributor.authorDokekias, A.Eliraen_US
dc.date.accessioned2023-08-25T07:35:59Z
dc.date.available2023-08-25T07:35:59Z
dc.date.issued2023-05
dc.description.abstractIntroduction: The avascular osteonecrosis of the femoral head (AOFH) is a common complication of sickle cell disease (SCD). It exposes to lameness and sometimes to a very debilitating handicap. It is a source of desocialization, particularly in developing countries where prosthetic surgery remains inaccessible to the majority. This survey aimed to identify the risk of occurence AOFH. Materials and Methods: It was a case-control study carried between october 2017 and september 2021 at the National Reference Center for SCD « Antoinette Sassou Nguesso » in Brazzaville. It concerned 31 children with clinical and radiographic signs of AOFH. Clinical (age at diagnosis of SCD, frequency of vasoocclusive crises and hospitalization for vasoocclusive crises, number of blood transfusion) as well as hematological examination (blood count in the intercritical period) and hydroxyurea treatment were compared with those of 62 children with no clinical and radiographic signs of AOFH. The chi2 statistical test and the odds ratio were used for the comparison (P ˂ 0.05).Results: The sex ratio was 1.38 versus 0.93 (p = 0.50). The mean age of diagnostic of SCD was 3.76 ± 2.56 years versus 3.94 ± 2.01 years (p = 0.81). Logistic regression showed that SCD children with AOFH had a significantly higher rate of annual frequency of VOC (4.16 1.18 vs 2.91 1.68; P = 0.015), annual frequency of hospitalization for VOC (3.741.65 vs 1.451.28; P = 0.000) and number of blood transfusions (3.38 ± 2.69 vs 2.42 ± 2.32; P = 0.03).Conclusion: Emphasis should be placed on the prevention and early management of acute complications of SCD. The role of hydroxyurea should be clarified by further work.en_US
dc.identifier.affiliationsNational Reference Center for Sickle Cell Disease, Brazzaville, Congoen_US
dc.identifier.affiliationsFaculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congoen_US
dc.identifier.affiliationsDepartment of Traumatology and Orthopedics, Teatching Hospital of Brazzaville, Congo.en_US
dc.identifier.citationAtipo-Tsiba F. O. Galiba, Bilongo-Bouyou A., Bango J. C., Samba J. A. Elira, Gatsongui B. M., Malanda F., Ngolet L. O., Dokekias A.Elira. Risk Factors of avascular Osteonecrosis of the Femoral Head in Children at the National ReferenceCenter for Sickle Cell Disease in Brazzaville, Congo. International Blood Research & Reviews. 2023 May; 14(4): 1-7en_US
dc.identifier.issn2321–7219
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225686
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume14en_US
dc.source.urihttps://dx.doi.org/10.9734/IBRR/2023/v14i4311en_US
dc.subjectAOFHen_US
dc.subjectchildrenen_US
dc.subjectfemoral headen_US
dc.subjectosteonecrosisen_US
dc.subjectrisk factorsen_US
dc.subjectsickle cell disease.en_US
dc.titleRisk Factors of avascular Osteonecrosis of the Femoral Head in Children at the National ReferenceCenter for Sickle Cell Disease in Brazzaville, Congoen_US
dc.typeJournal Articleen_US
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