Immunoglobulins and allergy mediators in bronchial asthma.

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dc.contributor.authorDhungat, A Jen_US
dc.contributor.authorDesai, S Aen_US
dc.contributor.authorKhatri, D Pen_US
dc.contributor.authorChari, Ven_US
dc.contributor.authorParikh, P Sen_US
dc.contributor.authorKhanchandani, D Len_US
dc.contributor.authorSalgaonkar, D Sen_US
dc.date.accessioned1990-08-01en_US
dc.date.accessioned2009-05-30T19:40:07Z
dc.date.available1990-08-01en_US
dc.date.available2009-05-30T19:40:07Z
dc.date.issued1990-08-01en_US
dc.description.abstractSeventy four young asthmatics were evaluated to establish the role of immunoglobulins and allergy mediators in clinical asthma. They were categorized into Group I (n = 38) or Group II (n = 36) when having mild or severe bronchospasm respectively. In some patients, reversibility of bronchospasm (n = 35), exercise challenge (n = 24) and intradermal allergy testing (n = 24) were also studied. Seventy subjects had raised IgE levels (greater than 100 KU/L) but these did not correlate with the severity of clinical or exercise induced asthma or with reversibility of bronchospasm. An IgE level greater than 1000 KU/L was associated with more number of positive skin tests. Group II subjects had a shorter blood recalcification time (p less than 0.01) and higher levels of IgG, histamine and serotonin (p less than 0.001). It appears that severe asthma is associated with activation of blood coagulation, and release of allergy mediators contributes to the evolution of bronchospasm. Total IgE predicts the utility of skin testing in asthma.en_US
dc.description.affiliationDepartment of Medicine, TN Medical College, Bombay.en_US
dc.identifier.citationDhungat AJ, Desai SA, Khatri DP, Chari V, Parikh PS, Khanchandani DL, Salgaonkar DS. Immunoglobulins and allergy mediators in bronchial asthma. Journal of the Association of Physicians of India. 1990 Aug; 38(8): 542-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/86987
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAsthma --immunologyen_US
dc.subject.meshBlood Coagulationen_US
dc.subject.meshHistamine --analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulins --analysisen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRespiratory Mechanicsen_US
dc.subject.meshSerotonin --analysisen_US
dc.titleImmunoglobulins and allergy mediators in bronchial asthma.en_US
dc.typeJournal Articleen_US
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