Antimicrobial Sensitivity Pattern of Helicobacter pylori Isolates among Subgroup of Bangladeshi Patients.
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Date
2013-07
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Abstract
This cross sectional study was carried out at Bangabandhu Sheikh Mujib Medical University (BSMMU) and
International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) from July 2008 to September 2009.
Aim of the study was to find out the antimicrobial susceptibility profile of Helicobacter pylori isolates from dyspeptic
patients. Total 224 dyspeptic patients from Out Patient Department (OPD) of BSMMU were initially enrolled after
informed written consent. After upper GI endoscopy 157 patients were finally included who had erosions, ulcers or
atrophic changes in the stomach or duodenum. Two biopsy samples were taken from each of them. Samples were
incubated at 370C in a double gas incubator with 5%O2, 10%CO2 and 85%N2. Total 82 (52.23%) samples were found
positive for H. pylori. Isolated organisms were then tested for sensitivity to Amoxicillin, Clarithromycin,
Tetracycline, Levofloxacin and Metronidazole by Agar dilution method. Among 82 patients 51(62.2%) were male and
31(37.8) were female with a male:female ratio 1.6:1. Patients were categorized into two groups one having gastric or
duodenal ulcer (30.5%) and other having no ulcer (69.5%). Among these isolates 92.7% were sensitive to
Amoxicillin, 89% to Clarithromycin, 81.7% to Tetracycline, 80.5% to Levofloxacin and only 26.8% to
Metronidazole. Beside these, 81.7% isolates were sensitive to both Amoxicillin and Clarithromycin, 74.4% to
Amoxicillin and Tetracycline, 73.2% to Amoxicillin and Levofloxacin, 72% to Clarithromycin and Tetracycline, 59%
to Clarithromycin and Levofloxacin and 51% to Tetracycline and Levofloxacin.
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Keywords
Helicobacter pylori, Culture and sensitivity, Antimicrobials, Ulcer, Erosions
Citation
Islam M M S U, Nahar S, Sarker M N, Salimullah A S M, Rahman M A, Ahmed D S, Hasan M Q, Raihan A S M A, Bhuiyhan M R, Sarker S A.Antimicrobial Sensitivity Pattern of Helicobacter pylori Isolates among Subgroup of Bangladeshi Patients.Faridpur Medical College Journal. 2013 July; 8(2): 49-52.