Drug resistance in epilepsy and the ABCB1 gene: The clinical perspective.

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dc.contributor.authorDas, Abhijit
dc.contributor.authorBalan, Shabeesh
dc.contributor.authorBanerjee, Moinak
dc.contributor.authorRadhakrishnan, Kurupath
dc.date.accessioned2012-06-12T05:56:38Z
dc.date.available2012-06-12T05:56:38Z
dc.date.issued2011-05
dc.description.abstractMultidrug resistance is one of the most serious problems in the treatment of epilepsy that is likely to have a complex genetic and acquired basis. Various experimental data support the hypothesis that over-expression of antiepileptic drug (AED) transporters may play a pivotal role in drug resistance. Hyyt 6however, key questions concerning their functionality remain unanswered. The idea that P-glycoprotein, encoded by the ABCB1 gene, might mediate at least part of the drug resistance was met with both enthusiasm and skepticism. As in oncology, initial optimism has been clouded subsequently by conflicting results. The first study reporting a positive association between genetic variation in the P-glycoprotein and multidrug-resistant epilepsy was published in 2003. Since then, several other genetic association studies have attempted to verify this result. However, taken overall, the role of P-glycoprotein in drug resistance in epilepsy still remains uncertain. We intend to critically review the inherent problems associated with epilepsy pharmacogenetic studies in general and with ABCB1 polymorphisms studies in particular. The lessons learnt from the ABCB1 studies can help us to guide future association genetics studies to investigate AED resistance, and thereby taking us closer to the cherished dream of personalized AED therapy.en_US
dc.identifier.citationDas Abhijit, Balan Shabeesh, Banerjee Moinak, Radhakrishnan Kurupath. Drug resistance in epilepsy and the ABCB1 gene: The clinical perspective. Indian Journal of Human Genetics. 2011 May; 17(Suppl 1): 12-21.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/138979
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125047/en_US
dc.subjectABCB1en_US
dc.subjectantiepileptic drugsen_US
dc.subjectdrug resistanceen_US
dc.subjectepilepsyen_US
dc.subjectgenetic association studiesen_US
dc.subjectgenome-wide association studiesen_US
dc.subjectP-glycoproteinen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subject.meshAnticonvulsants
dc.subject.meshDrug Resistance--genetics
dc.subject.meshEpilepsy --drug therapy
dc.subject.meshGenetic Association Studies --methods
dc.subject.meshGenome-Wide Association Study --methods
dc.subject.meshHumans
dc.subject.meshP-Glycoprotein --genetics
dc.subject.meshPolymorphism, Single Nucleotide --genetics
dc.titleDrug resistance in epilepsy and the ABCB1 gene: The clinical perspective.en_US
dc.typeArticleen_US
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