Serum urocortin in preterm labor is it an effective biomarker?

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dc.contributor.authorRund, Nancy Mohamed Alien_US
dc.date.accessioned2020-10-16T07:56:45Z
dc.date.available2020-10-16T07:56:45Z
dc.date.issued2019-06
dc.description.abstractBackground: Preterm labor classically defined as delivery before completed 37 gestational weeks. Urocortin a biomarker that have raised recent research interest is a 40-amino acid neuropeptide related to the corticotrophin-releasing factor molecular family. Interestingly urocortin is produced by gestational tissue such as amnion and chorion predictability of preterm labor by biomarker assay could enhance management levels particularly in cases of preterm labor that are considered a frequent clinical scenario in obstetric practice. Aim of the study was to assess and evaluate the serum levels of urocortin predictability capacity in cases that develop preterm labor.Methods: The current research clinical trial was conducted in a prospective way there was two research groups 60 study subjects had threatened preterm labor and 60 normal research study subjects that delivered at term. Comparative analysis was performed for urocortin assay conducted in both research groups in correlation to gathered clinical data obtained from both research groups.Results: Receiver operating characteristic curve (ROC) between preterm and term delivery research groups as regards plasma urocortin level (pg/ml) as a predictor of pre term delivery showing that a cut-off point level >101.3 pg/ml in which statistical sensitivity=88.33%, statistical specificity=75%, positive predictive value=77.9, negative predictive value=86.5.Conclusions: This research finding reveal that maternal serum urocortin is an effective biomarker in predictability of preterm labor; however future research studies should be multicentric in fashion putting in consideration the racial and ethnic differences besides the impact of BMI on maternal serum urocortin indices.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, Ain Shams University, Cairo, Egypten_US
dc.identifier.citationRund Nancy Mohamed Ali. Serum urocortin in preterm labor is it an effective biomarker?. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2019 Jun; 8(6): 2522-2527en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206816
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20192461en_US
dc.subjectBiomarkeren_US
dc.subjectMyometrial contractilityen_US
dc.subjectPreterm laboren_US
dc.subjectUrocortinen_US
dc.subjectUteroplacental perfusionen_US
dc.titleSerum urocortin in preterm labor is it an effective biomarker?en_US
dc.typeJournal Articleen_US
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