Probing tenability of biochemical vis-a-vis physicochemical interpretations of modulation of radiation damage by caffeine and cysteine in barley.

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dc.contributor.authorSah, N Ken_US
dc.contributor.authorKesavan, P Cen_US
dc.date.accessioned1996-10-01en_US
dc.date.accessioned2009-05-27T09:45:21Z
dc.date.available1996-10-01en_US
dc.date.available2009-05-27T09:45:21Z
dc.date.issued1996-10-01en_US
dc.description.abstractCysteine (an aminothiol) is known to protect against radiation damage, and is understood to do so by generating hydrogen peroxide which subsequently inhibits RNA synthesis. Our results showed inability of catalase to remove or reduce the magnitude of radioprotection by caffeine and/or cysteine at optimal/suboptimal temperatures in barley. This observation was adequately corroborated by data on frequency of chromosomal aberration, peroxidase activity and total protein content. On the contrary, catalase tended to enhance the radioprotective effectiveness of cysteine. Macromolecular synthetic patterns in caffeine and/or cysteine treated embryos were too inconsistent to permit a logical conclusion with regard to their positive involvement in the biochemical pathway of chemical modification of radiation damage. On the other hand, mutually annihilatory reaction hypothesis based on physico-chemical principles provides a satisfactory explanation for the observed effects.en_US
dc.description.affiliationSchool of Life Sciences, Jawaharlal Nehru University, New Delhi, India.en_US
dc.identifier.citationSah NK, Kesavan PC. Probing tenability of biochemical vis-a-vis physicochemical interpretations of modulation of radiation damage by caffeine and cysteine in barley. Indian Journal of Biochemistry & Biophysics. 1996 Oct; 33(5): 384-90en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28464
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshCaffeine --pharmacologyen_US
dc.subject.meshCatalase --metabolismen_US
dc.subject.meshChemistry, Physicalen_US
dc.subject.meshCysteine --pharmacologyen_US
dc.subject.meshHordeum --drug effectsen_US
dc.subject.meshHydrogen Peroxide --metabolismen_US
dc.subject.meshPhysicochemical Phenomenaen_US
dc.subject.meshRNA, Plant --biosynthesisen_US
dc.subject.meshRadiation-Protective Agents --pharmacologyen_US
dc.titleProbing tenability of biochemical vis-a-vis physicochemical interpretations of modulation of radiation damage by caffeine and cysteine in barley.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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