Investigation of the antibacterial activity of synthesized hydroxyapatite Sr-doped nanocomposite

dc.contributor.authorJamarun, Nen_US
dc.contributor.authorAfriskaa, LNen_US
dc.contributor.authorWelliaa, DVen_US
dc.contributor.authorPrasejatia, Aen_US
dc.contributor.authorAmirullaha, TYen_US
dc.contributor.authorWulandariaen_US
dc.contributor.authorTrycahyania, NA.en_US
dc.date.accessioned2024-11-30T11:21:20Z
dc.date.available2024-11-30T11:21:20Z
dc.date.issued2024-09
dc.description.abstractHydroxyapatite is a mineral compound with a composition resembling the components found in human teeth and bones. Hydroxyapatite possesses osteoconductive, bioactive, and biocompatible characteristics. Nevertheless, hydroxyapatite has limitations, particularly its limited antibacterial activity. Therefore, this research uses the sol-gel method to synthesize and characterize strontium hydroxyapatite doped composites (HAp-Sr doped composites). The calcium precursor used in this research comes from the green mussel shells (Perna viridis); the main component is CaCO3 , which will later be converted into CaO compounds. HAp Sr-doped composites were synthesized by varying the concentration of Sr metal (5%, 10%, and 20% w/w), which aimed to determine its good antibacterial ability. The X-ray fluorescence analysis reveals that green mussel shells contain 97.261% calcium oxide (CaO). The X-ray diffraction analysis reveals that the pattern observed at an angle of 2? corresponds to the hydroxyapatite standard from ICDD (No.96-101-1243), which possesses a hexagonal structure. The Fourier transform infrared spectroscopy spectra reveal the presence of PO4 3? groups in the sample at wave numbers 528 cm?1, 604 cm?1, 945 cm?1, and 1,018 cm?1. The antibacterial activity of the HAp-Sr doped composite was evaluated against Staphylococcus aureus and Escherichia coli bacteria. The results indicated that the 5% HAp-Sr doped composite exhibited antibacterial activity. Therefore, it can potentially be utilized in bone grafts and implants.en_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, Indonesiaen_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, Indonesiaen_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, Indonesiaen_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, Indonesiaen_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, Indonesiaen_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, Indonesiaen_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, Indonesia.en_US
dc.identifier.citationJamarun N, Afriskaa LN, Welliaa DV, Prasejatia A, Amirullaha TY, Wulandaria, Trycahyania NA. . Investigation of the antibacterial activity of synthesized hydroxyapatite Sr-doped nanocomposite. Journal of Applied Pharmaceutical Science. 2024 Sept; 14(9): 264-269en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237706
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber9en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.7324/JAPS.2024.178833en_US
dc.subjectHydroxyapatiteen_US
dc.subjectstrontium dopeden_US
dc.subjectgreen mussel shellsen_US
dc.subjectantibacterial activity.en_US
dc.titleInvestigation of the antibacterial activity of synthesized hydroxyapatite Sr-doped nanocompositeen_US
dc.typeJournal Articleen_US
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