Dengue hemorrhagic fever: clinical manifestations and management.

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dc.contributor.authorKabra, S Ken_US
dc.contributor.authorJain, Yen_US
dc.contributor.authorSinghal, Ten_US
dc.contributor.authorRatageri, V Hen_US
dc.date.accessioned1999-01-08en_US
dc.date.accessioned2009-05-30T10:31:22Z
dc.date.available1999-01-08en_US
dc.date.available2009-05-30T10:31:22Z
dc.date.issued1999-01-08en_US
dc.description30 references.en_US
dc.description.abstractDengue virus infection may remain asymptomatic or manifest as nonspecific viral infection to life threatening dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Patients with DHF/DSS have fever, hemorrhagic manifestations along with thrombocytopenia and hemoconcentration. Thrombocytopenia and hemoconcentration are distinguishing features between DHF/DSS and dengue fever (DF). Some patients with dengue fever may have significant bleed and mild thrombocytopenia but no hemoconcentration. These patients are labelled to have dengue fever with unusual bleeds. Laboratory findings in DHF/DSS include rising hematocrit, thrombocytopenia and transformed lymphocytes on peripheral smear. There may be increased transaminases, hyponatremia, transient increase in blood urea nitrogen and creatinine. In severe disease there may be lab evidence of dissemination intravascular coagulation. X-ray film of the chest may show pleural-effusion. Ultrasonogram of abdomen may detect thickened gall bladder wall with hepatomegaly and ascitis. In some patients there may be abnormality in electrocardiogram and echocardiogram. The diagnosis of DHF/DSS is based on typical clinical findings. For confirmation of dengue virus infection viral culture can be done on blood obtained from patients during early phase of illness. In later part of illness antibodies against dengue virus can be demonstrated by various techniques. The treatment of DF is symptomatic. For control of fever nonsteroidal anti-inflammatory drugs should be avoided. DHF/DSS are managed by intravenous fluid infusion with repeated monitoring of vital parameters and packed cell volume (PCV).en_US
dc.description.affiliationDepartment of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.en_US
dc.identifier.citationKabra SK, Jain Y, Singhal T, Ratageri VH. Dengue hemorrhagic fever: clinical manifestations and management. Indian Journal of Pediatrics. 1999 Jan-Feb; 66(1): 93-101en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/78733
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAcetaminophenen_US
dc.subject.meshDengue Hemorrhagic Fever --classificationen_US
dc.subject.meshDengue Virus --isolation & purificationen_US
dc.subject.meshFluid Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunologic Testsen_US
dc.subject.meshMonitoring, Physiologicen_US
dc.titleDengue hemorrhagic fever: clinical manifestations and management.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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