Dysthyroid optic neuropathy: Demographics, risk factors, investigations, and management outcomes

Simple item page
dc.contributor.authorPoonam, Nisar Sonamen_US
dc.contributor.authorAlam, Md. Shahiden_US
dc.contributor.authorOberoi, Prashanten_US
dc.contributor.authorMukherjee, Bipashaen_US
dc.date.accessioned2023-08-25T06:35:32Z
dc.date.available2023-08-25T06:35:32Z
dc.date.issued2022-12
dc.description.abstractPurpose: To analyze the clinical presentations, risk factors, and management outcomes in patients presenting with dysthyroid optic neuropathy (DON). Methods: This is a retrospective, single?center study carried out on consecutive patients presenting with DON over a period of 4 years (2013–2016). The VISA classification was used at the first visit and subsequent follow?ups. The diagnosis was based on optic nerve function tests and imaging features. Demographic profiles, clinical features, risk factors, and management outcomes were analyzed. Results: Thirty?seven eyes of 26 patients diagnosed with DON were included in the study. A significant male preponderance was noted (20, 76.92%). Twenty patients (76.9%, P = 0.011) had hyperthyroidism, and 15 (57.69%, P = 0.02) were smokers. Decreased visual acuity was noted in 28 eyes (75.6%). Abnormal color vision and relative afferent pupillary defects were seen in 24 (64.86%) eyes, and visual field defects were seen in 30 (81.01%) eyes. The visual evoked potential (VEP) showed a reduced amplitude in 30 (96.77%, P = 0.001) of 31 eyes and delayed latency in 20 (64.51%, P = 0.0289) eyes. Twenty?six (70.27%) patients were treated with intravenous methyl prednisolone (IVMP) alone, whereas 11 (29.72%) needed surgical decompression. The overall best?corrected visual acuity improved by 0.2 l logMARunits. There was no statistically significant difference in outcome between medically and surgically treated groups. Four patients developed recurrent DON, and all of them were diabetics. Conclusion: Male gender, hyperthyroid state, and smoking are risk factors for developing DON. VEP, apical crowding, and optic nerve compression are sensitive indicators for diagnosing DON. Diabetics may have a more defiant course and are prone to develop recurrent DON.en_US
dc.identifier.affiliationsOrbit, Oculoplasty, Reconstructive and Aesthetic Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Indiaen_US
dc.identifier.affiliationsOrbit, Oculoplasty, Reconstructive & Aesthetic Services, Aditya Birla Sankara Nethralaya, Kolkata, West Bengal, India (A Unit of Medical Research Foundation, Chennai)en_US
dc.identifier.citationPoonam Nisar Sonam, Alam Md. Shahid, Oberoi Prashant, Mukherjee Bipasha. Dysthyroid optic neuropathy: Demographics, risk factors, investigations, and management outcomes. Indian Journal of Ophthalmology. 2022 Dec; 70(12): 4419-4426en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224759
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber12en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_719_22en_US
dc.subjectDysthyroid optic neuropathyen_US
dc.subjectThyroid orbitopathyen_US
dc.subjectVisual evoked potentialen_US
dc.titleDysthyroid optic neuropathy: Demographics, risk factors, investigations, and management outcomesen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJO2022v70n12p4419.pdf
Size:
3.58 MB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Ophthalmology