Evaluation of katG codon 315 mutations among isoniazid sensitive and resistant mycobacterium tuberculosis isolates from Thailand.

Simple item page
dc.contributor.authorImwidthaya, Pen_US
dc.contributor.authorMieskes, Ken_US
dc.contributor.authorRienthong, Sen_US
dc.date.accessioned2009-05-27T19:11:27Z
dc.date.available2009-05-27T19:11:27Z
dc.date.issued2001-06-15en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractNine isoniazid (INH)-susceptible and 11 INH-resistant Mycobacterium tuberculosis clinical isolates were analyzed for katG codon 315 mutations by polymerase chain reaction (PCR) assay using primers MYC-32 and MYC-33, followed by restriction fragment length polymorphism. After AciI digestion of PCR products, all 9 INH-susceptible isolates and 5 out of 11 (45%) INH-resistant isolates showed 0.12 kb band, which was previously reported to indicate wild type, whereas, 6 of 11 (55%) INH-resistant isolates lacked this band.en_US
dc.description.affiliationDepartment of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationImwidthaya P, Mieskes K, Rienthong S. Evaluation of katG codon 315 mutations among isoniazid sensitive and resistant mycobacterium tuberculosis isolates from Thailand. Journal of the Medical Association of Thailand. 2001 Jun; 84(6): 864-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40645
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAntitubercular Agents --pharmacologyen_US
dc.subject.meshBacterial Proteinsen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoniazid --pharmacologyen_US
dc.subject.meshMutationen_US
dc.subject.meshMycobacterium tuberculosis --drug effectsen_US
dc.subject.meshPeroxidases --geneticsen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.titleEvaluation of katG codon 315 mutations among isoniazid sensitive and resistant mycobacterium tuberculosis isolates from Thailand.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Medical Association of Thailand