Effect of early luteal phase administration of a single dose mifepristone on immunohistochemical distribution of interleukin 1 alpha (IL-1 alpha) and transforming growth factor beta 1 (TGF-beta 1) in mid-luteal phase ovary of the rhesus monkey.

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dc.contributor.authorSengupta, Shaonen_US
dc.contributor.authorGhosh, Den_US
dc.date.accessioned2003-04-17en_US
dc.date.accessioned2009-06-01T07:12:31Z
dc.date.available2003-04-17en_US
dc.date.available2009-06-01T07:12:31Z
dc.date.issued2003-04-17en_US
dc.description.abstractA single low dose administration of a high affinity anti-progestin agent like mifepristone during the early luteal phase inhibits blastocyst implantation in human and non-human primates. Though it has been observed that luteal phase serum concentrations of estradiol and progesterone were not affected by the application of anti-nidatory dose of early luteal phase mifepristone suggesting that ovarian steroidogenic function is not compromised, it is nevertheless possible that ovarian physiology at the local tissue level is affected in this treatment schedule. In the present study, healthy, mature, proven fertile female rhesus monkeys were divided into two groups. Group 2 animals were treated with a single dose of mifepristone (2 mg/kg body weight), while group 1 animals were injected with vehicle (1:4 benzoyl benzoate: olive oil, v/v, s.c.) on day 2 post-ovulation. The morphological examination including that of vascularity, as well as, histometric determination of profiles of immunopositivity for IL-1alpha and TGF-beta1 in stromal, follicular and luteal compartments of mid-luteal phase ovaries from animals with or without a single, anti-nidatory dose of mifepristone applied on day 2 after ovulation failed to reveal any significant change between the two groups. Thus, it appears that early luteal phase administration of a single antinidatory dose of mifepristone does not affect the ovarian physiology in the treatment cycle.en_US
dc.description.affiliationDepartment of Physiology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSengupta S, Ghosh D. Effect of early luteal phase administration of a single dose mifepristone on immunohistochemical distribution of interleukin 1 alpha (IL-1 alpha) and transforming growth factor beta 1 (TGF-beta 1) in mid-luteal phase ovary of the rhesus monkey. Indian Journal of Physiology and Pharmacology. 2003 Apr; 47(2): 221-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107979
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFemaleen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshInterleukin-1 --metabolismen_US
dc.subject.meshLuteal Phase --drug effectsen_US
dc.subject.meshMacaca mulattaen_US
dc.subject.meshMifepristone --administration & dosageen_US
dc.subject.meshOvary --drug effectsen_US
dc.subject.meshProtein Subunits --metabolismen_US
dc.subject.meshTransforming Growth Factor beta --metabolismen_US
dc.subject.meshTransforming Growth Factor beta1en_US
dc.titleEffect of early luteal phase administration of a single dose mifepristone on immunohistochemical distribution of interleukin 1 alpha (IL-1 alpha) and transforming growth factor beta 1 (TGF-beta 1) in mid-luteal phase ovary of the rhesus monkey.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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