Clinical and biochemical parameters in relation to serum leptin levels in south indian children and adolescents.

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dc.contributor.authorRao, G Srinivasa Nageswara
dc.contributor.authorGurumurthy, Prema
dc.contributor.authorGururajan, Priya
dc.contributor.authorArumugam, Sarasa Barathi
dc.contributor.authorSaibabu
dc.contributor.authorKirthivasan, V
dc.contributor.authorCherian, K M
dc.date.accessioned2012-10-30T04:00:53Z
dc.date.available2012-10-30T04:00:53Z
dc.date.issued2010-05
dc.description.abstractObjective. To investigate the relationship between serum leptin and lipid profile in South Indian School children and adolescents, and to evaluate the role of serum leptin in obese, overweight and congenital heart diseased children and adolescents; in South Indian population and its correlation with anthropometric and biochemical parameters. Methods. The study included 185 school going children and adolescents. (52 obese, 49 overweight, 25 congenital heart disease children and adolescents, were compared with 59 normal controls, aged between 10-17 years). Anthropometric variables, lipid profile, fasting serum glucose were analyzed by autoanalyser and serum leptin by ELISA. Results. Serum leptin levels were significantly elevated in obese and overweight children than in control children (36.88±18.60ng/mL, 20.64±11.18ng/mL vs 7.97±2.79ng/mL; p value <0.001), and decreased in congenital heart diseased children than in control children (6.20±4.23 ng/mL vs 7.97±2.79ng/mL; p value <0.005). Conclusions. This study provides a good relationship between serum leptin levels and anthropometric and biochemical parameters, such as total cholesterol, triglycerides and LDL-cholesterol. We observed negative correlation between serum leptin and fasting glucose levels and HDL-cholesterol levels were found to be non-significant among the groups. Further studies with large sample size are needed to ascertain the relationship between serum leptin and lipid profile in different groups of children and adolescents.en_US
dc.identifier.citationRao G Srinivasa Nageswara, Gurumurthy Prema, Gururajan Priya, Arumugam Sarasa Barathi, Saibabu, Kirthivasan V, Cherian K M. Clinical and biochemical parameters in relation to serum leptin levels in south indian children and adolescents. Indian Journal of Pediatrics. 2010 May; 77(5): 555-559.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142579
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/icb/t10/i5/icbt10i5p555.pdfen_US
dc.subjectLeptinen_US
dc.subjectOverweighten_US
dc.subjectObesityen_US
dc.subjectCongenital heart diseaseen_US
dc.subject.meshAdolescent
dc.subject.meshAnalysis of Variance
dc.subject.meshAnthropometry
dc.subject.meshBiological Markers --blood
dc.subject.meshCase-Control Studies
dc.subject.meshChild
dc.subject.meshFemale
dc.subject.meshHeart Defects, Congenital --blood
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshLeptin --blood
dc.subject.meshLipids --blood
dc.subject.meshMale
dc.subject.meshObesity --blood
dc.subject.meshOverweight --blood
dc.titleClinical and biochemical parameters in relation to serum leptin levels in south indian children and adolescents.en_US
dc.typeArticleen_US
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