Therapeutics Effects of the Genus Citrus in Anxiety Disorder

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dc.contributor.authorKaur, Hen_US
dc.contributor.authorKaushik, Uen_US
dc.contributor.authorChoudhary, N.en_US
dc.date.accessioned2025-05-12T10:22:28Z
dc.date.available2025-05-12T10:22:28Z
dc.date.issued2024-12
dc.description.abstractBackground: Anxiety and mood disorders are among the mental health diseases that have exponentially increased in preva- lence owing to the hectic and stressful lifestyle. In addition to negatively impacting people’s physical health, this has resulted in a major psychological, social, and financial burden. A lot of emphasis has been placed on dietary and lifestyle modifications in the ongoing search for medication-free treatments. Investigating the connection between the consumption of specific fruits and vegetables and mental health issues such as depression has produced some intriguing and occasionally encouraging results. The genus Citrus with over 1300 species of plants is enriched with a plethora of polyphenolic compounds on the one hand and multicomponent volatile oil content on the other hand. Purpose: The current work is centered on examining the range of phytoconstituents found in various citrus species—both underutilized and utilized—as promising avenues for future anxiolytic research. The work also details the proposed pharma- cological mechanisms of isolated components and clinical trial advancements of selected citrus species. Methodology: Various databases, including PubMed and ScienceDirect, were used to search and collect relevant litera- ture published in the past 10 years (2014–2024). The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) criteria recommended for drafting methodical reviews were followed. Results: Initially, 1791 articles were collected through an electronic database search, irrelevant titles/abstracts (1449) and other types of articles (05) were excluded. Out of 342 assessed reports, 187 duplicate articles were excluded. Finally, list of 67 articles was included in this narrative review. Conclusion: Although research and development, as well as the commercial use of several citrus varieties, have attracted some interest recently, analyzing neglected citrus species closely can help to improve their processing into well-known anx- iolytic leads by revealing their untapped potential. The work emphasizes the extensive exploration of underutilized citrus species, which have a rich bioactive pro file and enormous potential in pharmaceutical research and development.en_US
dc.identifier.affiliationsDepartment of Pharmacognosy, Chitkara College of Pharmacy, Rajpura, Punjab, India; Department of Pharmacognosy, School of Pharmaceutical Sciences, RIMT University, Mandi Gobindgarh, Punjab, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacognosy, Chitkara College of Pharmacy, Rajpura, Punjab, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacognosy, GNA School of Pharmacy, GNA University, Phagwara, Punjab, Indiaen_US
dc.identifier.citationKaur H, Kaushik U, Choudhary N.. Therapeutics Effects of the Genus Citrus in Anxiety Disorder. Journal of Pharmacology and Pharmacotherapeutics. 2024 Dec; 15(4): 373-388en_US
dc.identifier.issn0976-500X
dc.identifier.issn0976-5018
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247669
dc.languageenen_US
dc.publisherSage Publications India Pvt. Ltd.en_US
dc.relation.issuenumber4en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.1177/0976500X241278037en_US
dc.subjectAnxietyen_US
dc.subjectanxiolyticen_US
dc.subjectC. maximaen_US
dc.subjectC. medicaen_US
dc.subjectC. reticulataen_US
dc.subjectCitrusen_US
dc.titleTherapeutics Effects of the Genus Citrus in Anxiety Disorderen_US
dc.typeJournal Articleen_US
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