Immunologic & pulmonary function abnormalities in tropical pulmonary eosinophilia.

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dc.contributor.authorSharma, S Ken_US
dc.contributor.authorPande, J Nen_US
dc.contributor.authorKhilnani, G Cen_US
dc.contributor.authorVerma, Ken_US
dc.contributor.authorKhanna, Men_US
dc.date.accessioned1995-03-01en_US
dc.date.accessioned2009-05-27T07:02:21Z
dc.date.available1995-03-01en_US
dc.date.available2009-05-27T07:02:21Z
dc.date.issued1995-03-01en_US
dc.description.abstractTwenty six patients (24 males and 2 females) with tropical pulmonary eosinophilia (TPE) were studied. Arterial blood gas analysis, pulmonary functions, peripheral blood examination and bronchoalveolar lavage (BAL) were performed. Peripheral blood and BAL fluid analyses were performed in healthy volunteers. Pulmonary functions revealed a mild restrictive ventilatory defect with airways obstruction. Mild hypoxaemia was observed on arterial blood gas analysis. Serum immunoglobulins IgG (P < 0.01), IgA (P < 0.001) and IgM (P < 0.001) were significantly raised as compared to normal controls. Serum complement (C3) level was higher, however, it was not significantly different as compared to normal controls. Serum haemolytic component of the complement (CH50) was significantly higher (P < 0.001) in patients with TPE compared to normal control subjects. The immunoglobulins IgG, IgA and IgM in the BAL fluid were significantly (P < 0.001) increased as compared to normal controls. The fibronectin (FN) level was also significantly increased (P < 0.001) in the BAL fluid. It is concluded that patients with TPE have mild restrictive ventilatory defect with airways obstruction and mild hypoxaemia. They have eosinophilic alveolitis with increased levels of immunoglobulins in the peripheral blood and BAL fluid. The significance of elevated FN in the BAL fluid is not clear and serial estimations may have to be done in order to clarify its role in the pathogenesis of fibrosis in chronic TPE.en_US
dc.description.affiliationDepartment of Medicine, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSharma SK, Pande JN, Khilnani GC, Verma K, Khanna M. Immunologic & pulmonary function abnormalities in tropical pulmonary eosinophilia. Indian Journal of Medical Research. 1995 Mar; 101(): 98-102en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19033
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBronchoalveolar Lavage Fluid --chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibronectins --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPulmonary Eosinophilia --immunologyen_US
dc.subject.meshRespiratory Function Testsen_US
dc.titleImmunologic & pulmonary function abnormalities in tropical pulmonary eosinophilia.en_US
dc.typeJournal Articleen_US
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