Dynamics of Met5- and Leu5-enkephalin and their receptor binding activity in relation to morphine.

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dc.contributor.authorMishra, Nen_US
dc.contributor.authorTandon, Pen_US
dc.contributor.authorGupta, V Den_US
dc.contributor.authorGupta, V Pen_US
dc.date.accessioned1994-02-01en_US
dc.date.accessioned2009-05-27T09:32:03Z
dc.date.available1994-02-01en_US
dc.date.available2009-05-27T09:32:03Z
dc.date.issued1994-02-01en_US
dc.description.abstractA complete normal coordinate analysis of Met5- and Leu5-enkephalins using Wilson's GF matrix method and Urey Bradley force field has been carried out to understand the dynamical behaviour of enkephalins. In addition, the charge distributions on different atoms of the two enkephalins and morphine using CNDO/2 method are also reported. The similarity in the charge distribution on the part of these two molecules is indicative of the possible interactions at the same receptor site as that of morphine and its derivatives. Apart from the topographical features and charge distribution, binding onto receptor site is not a static but a dynamic process and low frequency modes must play an important role in the recognition process. The significance of the out-of-plane amide VII band and other skeletal modes as characteristic of conformational states of Met5- and Leu5-enkephalins are discussed.en_US
dc.description.affiliationPhysics Department, Lucknow University, India.en_US
dc.identifier.citationMishra N, Tandon P, Gupta VD, Gupta VP. Dynamics of Met5- and Leu5-enkephalin and their receptor binding activity in relation to morphine. Indian Journal of Biochemistry & Biophysics. 1994 Feb; 31(1): 43-54en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27795
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshEnkephalin, Leucine --metabolismen_US
dc.subject.meshEnkephalin, Methionine --metabolismen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshMorphine --metabolismen_US
dc.subject.meshReceptors, Opioid --metabolismen_US
dc.titleDynamics of Met5- and Leu5-enkephalin and their receptor binding activity in relation to morphine.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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