Molecular mechanisms of HIV-1 associated neurodegeneration.

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dc.contributor.authorOzdener, Hakanen_US
dc.date.accessioned2005-06-30en_US
dc.date.accessioned2009-06-01T14:20:00Z
dc.date.available2005-06-30en_US
dc.date.available2009-06-01T14:20:00Z
dc.date.issued2005-06-30en_US
dc.description180 references.en_US
dc.description.abstractSince identification of the human immunodeficiency virus-1 (HIV-1), numerous studies suggest a link between neurological impairments, in particular dementia, with acquired immunodeficiency syndrome (AIDS) with alarming occurrence worldwide. Approximately, 60% of HIV-infected people show some form of neurological impairment, and neuropathological changes are found in 90% of autopsied cases. Approximately 30% of untreated HIV-infected persons may develop dementia. The mechanisms behind these pathological changes are still not understood. Mounting data obtained by in vivo and in vitro experiments suggest that neuronal apoptosis is a major feature of HIV associated dementia (HAD), which can occur in the absence of direct infection of neurons. The major pathway of neuronal apoptosis occurs indirectly through release of neurotoxins by activated cells in the central nervous system (CNS) involving the induction of excitotoxicity and oxidative stress. In addition a direct mechanism induced by viral proteins in the pathogenesis of HAD may also play a role. This review focuses on the molecular mechanisms of HIV-associated dementia and possible therapeutic strategies.en_US
dc.description.affiliationMonell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. hozdener@yahoo.comen_US
dc.identifier.citationOzdener H. Molecular mechanisms of HIV-1 associated neurodegeneration. Journal of Biosciences. 2005 Jun; 30(3): 391-405en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110754
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAIDS Dementia Complex --pathologyen_US
dc.subject.meshApoptosis --physiologyen_US
dc.subject.meshHIV-1 --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshNeuroglia --physiologyen_US
dc.subject.meshNeurons --physiologyen_US
dc.titleMolecular mechanisms of HIV-1 associated neurodegeneration.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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