A comparative study of metabolic parameters in diet-induced obesity model of rats

dc.contributor.authorGaur, Aen_US
dc.contributor.authorSakthivadivel, Ven_US
dc.contributor.authorMaithiliKarpagaselvi, Nen_US
dc.contributor.authorGhosh, S.en_US
dc.date.accessioned2023-06-27T06:36:40Z
dc.date.available2023-06-27T06:36:40Z
dc.date.issued2022-03
dc.description.abstractBackground: The occurrence of overweight and obesity coupled with many non-communicable diseases is a major preventable cause of premature morbidity and death. Sexual dimorphism exists in neural regulation of food intake. In spite of less consumption, females are prone to deposit greater amount of fat. Aim and Objective: This study aims to compare the effect of two different diets, high-fat diet (HFD) and sucrose diet with the normal chow eating rats correlating with various biochemical parameters. Materials and Methods: A total of 36 adult rats of both genders were selected. They were divided into three groups and each group was given fat diet, sucrose diet, and normal chow diet for 10 weeks. Biochemical analysis was done at the end of 10 weeks. Results: Food intake, body weight, glucose, insulin, and total cholesterol (TC) are significantly greater in males in comparison to females. Triglycerides and G/I ratio are found to be significantly greater in females. Insulin resistance was observed in both sucrose and HFD group but TC was higher in HFD group. Conclusion: Sucrose diet and HFD produce insulin resistance and dyslipidemia and it seems to be more pronounced in males compared to females. Sucrose diet has little effect on lipid parameters.en_US
dc.identifier.affiliationsDepartment of Physiology, All India Institute of Medical Sciences, Bibinagar, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of General Medicine, All India Institute of Medical Sciences, Bibinagar, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences, Bibinagar, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.citationGaur A, Sakthivadivel V, MaithiliKarpagaselvi N, Ghosh S.. A comparative study of metabolic parameters in diet-induced obesity model of rats. National Journal of Physiology, Pharmacy and Pharmacology. 2022 Mar; 12(3): 301-306en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217512
dc.languageenen_US
dc.publisherMrs Dipika Charan of MedScience (India) Publicationsen_US
dc.relation.issuenumber3en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2022.12.07228202106092021en_US
dc.subjectSucroseen_US
dc.subjectDieen_US
dc.subjectHigh faten_US
dc.subjectInsulin resistanceen_US
dc.subjectObesityen_US
dc.subjectLipid profileen_US
dc.titleA comparative study of metabolic parameters in diet-induced obesity model of ratsen_US
dc.typeJournal Articleen_US
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