Modulation of pain perception by ramipril and losartan in human volunteers.

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dc.contributor.authorKalra, Juhien_US
dc.contributor.authorChaturvedi, Aditien_US
dc.contributor.authorKalra, Sudhanshuen_US
dc.contributor.authorChaturvedi, Harishen_US
dc.contributor.authorDhasmana, D Cen_US
dc.date.accessioned2008-01-04en_US
dc.date.accessioned2009-06-01T06:13:40Z
dc.date.available2008-01-04en_US
dc.date.available2009-06-01T06:13:40Z
dc.date.issued2008-01-04en_US
dc.description.abstractThe angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are a well known entity and have been used in therapeutics for various indications like hypertension, myocardial infarction and CHF. However, there is a renewed interest in these compounds in terms of their effects on pain perception in animals as well as in human beings. They have yielded contradictory results, showing hyperalgesia in some studies but analgesia in others. Hence this study was undertaken to evaluate the effect of Ramipril (an ACE-I) and Losartan (an ARB) on pain perception in human volunteers using cola caps and handcuff of sphygmomanometer. A total of 30 healthy, normotensive individuals with no previous history of intake of analgesics during or 4 weeks prior to the study were selected after an informed consent. The first group received a single dose of placebo, the second group received Ramipril (2.5 mg) & the third group received Losartan (50 mg). Pain perception threshold (the point at which an individual first experiences pain) and the maximum tolerated pain were assessed using the above method. The control group showed no significant changes in pain threshold, but the group receiving either Ramipril or Losartan showed a decline in threshold for maximum tolerated pain. Only Ramipril and not Losartan decreased the pain perception threshold. Our study revealed that single dose treatment of healthy volunteers with Ramipril and Losartan may cause algesia as early as after ingestion of the first dose and further studies are needed to study their long term effects on pain perception.en_US
dc.description.affiliationDepartment of Pharmacology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun--248 140.en_US
dc.identifier.citationKalra J, Chaturvedi A, Kalra S, Chaturvedi H, Dhasmana DC. Modulation of pain perception by ramipril and losartan in human volunteers. Indian Journal of Physiology and Pharmacology. 2008 Jan-Mar; 52(1): 91-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107223
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAngiotensin II Type 1 Receptor Blockers --pharmacologyen_US
dc.subject.meshAngiotensin-Converting Enzyme Inhibitors --pharmacologyen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshHumansen_US
dc.subject.meshLosartan --pharmacologyen_US
dc.subject.meshPain --psychologyen_US
dc.subject.meshPain Measurement --drug effectsen_US
dc.subject.meshPain Threshold --drug effectsen_US
dc.subject.meshRamipril --pharmacologyen_US
dc.titleModulation of pain perception by ramipril and losartan in human volunteers.en_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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