Association of deletion in the chromosomal 8p21.3-23 region with the development of invasive head & neck squamous cell carcinoma in Indian patients.

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dc.contributor.authorBhattacharya, Nen_US
dc.contributor.authorTripathi, Aen_US
dc.contributor.authorDasgupta, Sen_US
dc.contributor.authorSabbir, Md Gen_US
dc.contributor.authorRoy, Aen_US
dc.contributor.authorSengupta, Aen_US
dc.contributor.authorRoy, Ben_US
dc.contributor.authorRoychowdhury, Sen_US
dc.contributor.authorPanda, C Ken_US
dc.date.accessioned2003-08-19en_US
dc.date.accessioned2009-05-27T06:24:35Z
dc.date.available2003-08-19en_US
dc.date.available2009-05-27T06:24:35Z
dc.date.issued2003-08-19en_US
dc.description.abstractBACKGROUND & OBJECTIVES: Deletions in chromosome 8 (chr.8) have been shown to be necessary for the development of head and neck squamous cell carcinoma (HNSCC). Attempts have been made in this study to detect the minimal deleted region in chr.8 associated with the development of HNSCC in Indian patients and to study the association of clinicopathological features with the progression of the disease. METHODS: The deletion mapping of chr.8 was done in samples from 10 primary dysplastic lesions and 43 invasive squamous cell carcinomas from the head and neck region of Indian patients to detect allelic alterations (deletion or size alteration) using 12 highly polymorphic microsatellite markers. The association of the highly deleted region was correlated with the tumour node metastasis (TNM) stages, nodal involvement, tobacco habit and human papilloma virus (HPV) infection of the samples. RESULTS: High frequency (49%) of loss of heterozygosity (LOH) was seen within 13.12 megabase (Mb) region of chromosomal 8p21.3-23 region in the HNSCC samples, whereas the dysplastic samples did not show any allelic alterations in this region. The highest frequency (17%) of microsatellite size alterations (MA) was observed in the chr.8p22 region. The loss of short arm or normal copy of chr.8 and rare bi-allelic alterations were seen in the stage II-IV tumours (939, 5184, 2772, 1319 and 598) irrespective of their primary sites. The highly deleted region did not show any significant association with any of the clinical parameters. However, HPV infection was significantly associated (P < 0.05) with the differentiation grades and overall allelic alterations (LOH/MA) of the samples. INTERPRETATION & CONCLUSION: Our data indicate that the 13.12 Mb deleted region in the chromosomal 8p21.3-23 region could harbour candidate tumour suppressor gene(s) (TSGs) associated with the progression anti invasion of HNSCC tumours in Indian patients.en_US
dc.description.affiliationDepartment of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata, India.en_US
dc.identifier.citationBhattacharya N, Tripathi A, Dasgupta S, Sabbir MG, Roy A, Sengupta A, Roy B, Roychowdhury S, Panda CK. Association of deletion in the chromosomal 8p21.3-23 region with the development of invasive head & neck squamous cell carcinoma in Indian patients. Indian Journal of Medical Research. 2003 Aug; 118(): 77-85en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/16079
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAllelesen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCarcinoma, Squamous Cell --geneticsen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosomes, Human, Pair 8en_US
dc.subject.meshDNA Primersen_US
dc.subject.meshFemaleen_US
dc.subject.meshHead and Neck Neoplasms --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshLoss of Heterozygosityen_US
dc.subject.meshMaleen_US
dc.subject.meshPapillomaviridae --isolation & purificationen_US
dc.titleAssociation of deletion in the chromosomal 8p21.3-23 region with the development of invasive head & neck squamous cell carcinoma in Indian patients.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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