Absence of mycobactin in Mycobacterium leprae; probably a microbe dependent microorganism implications.

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dc.contributor.authorKato, Len_US
dc.date.accessioned1985-01-01en_US
dc.date.accessioned2009-05-28T10:16:46Z
dc.date.available1985-01-01en_US
dc.date.available2009-05-28T10:16:46Z
dc.date.issued1985-01-01en_US
dc.description.abstractFerric mycobactins were prepared from Mycobacterium phlei. Mycobacterium avium--intracellulare A and H, isolated respectively from armadillo and human leprosy specimens. Attempts were made to extract mycobactin from host grown M. leprae cells. The crude ferric mycobactin extracts were tested for growth supporting effect on the mycobactin dependent M. paratuberculosis strain ATCC 19698. Mycobactins prepared from M. phlei and the two M. avium--intracellulare strains had growth promoting effect on M. paratuberculosis. The same test organism did not grow in media supplemented with the extract prepared from M. leprae. Results indicate the absence of mycobactin from host grown M. leprae. Since M. leprae cells contain cytochrome c and since mycobactin is essential to growth of all mycobacteria, M. leprae might be considered as a microbe dependent microbe. It is proposed that secondary mycobacteria present in M. leprae infected humans and armadillos might provide mycobactin for in vivo multiplication of M. leprae.en_US
dc.identifier.citationKato L. Absence of mycobactin in Mycobacterium leprae; probably a microbe dependent microorganism implications. Indian Journal of Leprosy. 1985 Jan-Mar; 57(1): 58-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55102
dc.language.isoengen_US
dc.subject.meshIron --metabolismen_US
dc.subject.meshMycobacterium --growth & developmenten_US
dc.subject.meshMycobacterium leprae --analysisen_US
dc.subject.meshOxazoles --analysisen_US
dc.titleAbsence of mycobactin in Mycobacterium leprae; probably a microbe dependent microorganism implications.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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