Inhibition of local effects of Indian Daboia/Vipera russelli venom by the methanolic extract of grape (Vitis vinifera L.) seeds.

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dc.contributor.authorMahadeswaraswamy, Y H
dc.contributor.authorDevaraja, S
dc.contributor.authorKumar, M S
dc.contributor.authorGoutham, Y N J
dc.contributor.authorKemparaju, K
dc.date.accessioned2011-11-09T05:14:10Z
dc.date.available2011-11-09T05:14:10Z
dc.date.issued2009-04
dc.description.abstractAlthough anti-venom therapy is available for the treatment of fatal bite by snakes, it offers less or no protection against the local effects such as dermo- and myonecrosis, edema, hemorrhage and inflammation at the bitten region. The viper species are known for their violent local effects and such effects have been commonly treated with plant extracts without any scientific validation in rural India. In this investigation, the methanolic extract of grapes (Vitis vinifera L.) seed was studied against the Indian Daboia/Vipera russelli venom-induced local effects. The extract abolished the proteolytic and hyaluronidase activities and also efficiently neutralized the hemorrhage, edema-inducing and myonecrotic properties of the venom. In addition, the extract also inhibited partially the pro-coagulant activity of the venom and abolished the degradation of Aα and Bβ chains of human fibrinogen. Thus, the extract possesses potent anti-snake venom property, especially against the local effects of viper bites.en_US
dc.identifier.citationMahadeswaraswamy Y H, Devaraja S, Kumar M S, Goutham Y N J, Kemparaju K. Inhibition of local effects of Indian Daboia/Vipera russelli venom by the methanolic extract of grape (Vitis vinifera L.) seeds. Indian Journal of Biochemistry & Biophysics. 2009 Apr; 46(2): 154-160.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135188
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/4051/1/IJBB%2046%282%29%20154-160.pdfen_US
dc.subjectHyaluronidaseen_US
dc.subjectLocal effectsen_US
dc.subjectMetalloproteaseen_US
dc.subjectNeutralizationen_US
dc.subjectSnake venomen_US
dc.subjectProteolytic activityen_US
dc.subjectHemorrhagic activityen_US
dc.subjectEdema-inducing activityen_US
dc.subjectMyonecrotic activityen_US
dc.subjectFibrinogenolytic activityen_US
dc.subjectPro-coagulant activityen_US
dc.subjectDaboia russellien_US
dc.subjectVipera russellien_US
dc.subjectGrape seeden_US
dc.subjectVitis vinifera L.en_US
dc.subject.meshAnimals
dc.subject.meshBlood Coagulation --drug effects
dc.subject.meshFibrinogen --metabolism
dc.subject.meshHemorrhage
dc.subject.meshHumans
dc.subject.meshHyaluronoglucosaminidase --antagonists & inhibitors
dc.subject.meshMethanol --chemistry
dc.subject.meshMice
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshRussell's Viper
dc.subject.meshSeeds --chemistry
dc.subject.meshViper Venoms --antagonists & inhibitors
dc.subject.meshViper Venoms --metabolism
dc.subject.meshViper Venoms --toxicity
dc.subject.meshVitis --chemistry
dc.titleInhibition of local effects of Indian Daboia/Vipera russelli venom by the methanolic extract of grape (Vitis vinifera L.) seeds.en_US
dc.typeArticleen_US
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