In vivo antioxidant and hepatoprotective potential of Glycyrrhiza glabra extract on carbon tetra chloride (CCl4) induced oxidative-stress mediated hepatotoxicity.
| dc.contributor.author | Sharma, Varsha | |
| dc.contributor.author | Agrawal, R C | |
| dc.date.accessioned | 2014-05-06T12:49:07Z | |
| dc.date.available | 2014-05-06T12:49:07Z | |
| dc.date.issued | 2014-01 | |
| dc.description.abstract | Objective: This study aimed to evaluate the antioxidant and hepatoprotective potential of Glycyrrhiza glabra hydromethanolic root extract against carbon tetra chloride (CCl4) induced oxidative-stress mediated hepatotoxicity in liver tissue of Swiss albino mice. Background: Medicinal plants play a vital role for the development of new drugs. Glycyrrhiza glabra is a widely used medicinal plant. It has many phyto-constituents and active components, which can be used for many diseases. Methods: For the antioxidant and hepatoprotective study, measurement of GSH, CAT, LPO bio-markers in Liver tissue of Swiss albino mice were taken. The animals were divided in six different groups each having 4 mice. The requisite dose of CCl4 was dissolved in appropriate solvent (1.5ml/kg body wt) and administrated as single i.p. dose per mice after 6 hr of last treatment of extract to the animals in each group. Mice were received orally administration of extract up to 7 days. Positive Control group received single i.p. injection of 1.5ml/kg body wt CCl4 in 0.9% saline. Results: The results suggest that, the crude extract of root of G. glabra at the doses of 300 and 600mg/kg body wt. expressed significant hepatoprotective potential against CCl4 induced oxidative stress mediated hepatotoxicity in student ‘t’ test (p<0.05) at dose dependent manner in the Liver tissue of Swiss albino mice. G. glabra root extract alone has not induced hepatotoxicity. Conclusion: Based on this study, It may be concluded that Glycyrrhiza glabra root extract possess hepatoprotective potential in Swiss albino mice. | en_US |
| dc.identifier.citation | Sharma Varsha, Agrawal R C. In vivo antioxidant and hepatoprotective potential of Glycyrrhiza glabra extract on carbon tetra chloride (CCl4) induced oxidative-stress mediated hepatotoxicity. International Journal of Research in Medical Sciences. 2014 Jan-Mar; 2(1): 314-320. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/150622 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.msjonline.org/Volume2Issue1/AbstIJRMS20140260.php | en_US |
| dc.subject | Antioxidant | en_US |
| dc.subject | CCl4 | en_US |
| dc.subject | Catalase | en_US |
| dc.subject | Glutathione | en_US |
| dc.subject | Glycyrrhiza glabra | en_US |
| dc.subject | Hepatotoxicity | en_US |
| dc.subject | Intraperitoneal | en_US |
| dc.subject | Liver | en_US |
| dc.subject | Oxidative stress | en_US |
| dc.title | In vivo antioxidant and hepatoprotective potential of Glycyrrhiza glabra extract on carbon tetra chloride (CCl4) induced oxidative-stress mediated hepatotoxicity. | en_US |
| dc.type | Article | en_US |