Immunohistological localisation of vascular endothelial growth factor in human endometrium.

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dc.contributor.authorNaresh, Ben_US
dc.contributor.authorSengupta, Jen_US
dc.contributor.authorBhargava, Ven_US
dc.contributor.authorKinra, Gen_US
dc.contributor.authorHu, Jen_US
dc.contributor.authorGhosh, Den_US
dc.date.accessioned1999-04-12en_US
dc.date.accessioned2009-06-01T05:20:40Z
dc.date.available1999-04-12en_US
dc.date.available2009-06-01T05:20:40Z
dc.date.issued1999-04-12en_US
dc.description.abstractSeveral polypeptide growth factors regulate epithelial and stromal development in endometrium under the influence of estrogen and progesterone, and thereby regulate growth and differentiation of endometrium during menstrual cycle. However, little is known about the angiogenic growth factors that may affect endometrial vasculature throughout each menstrual cycle. Vascular endothelial growth factor (VEGF) is suggestively an important angiogenic growth factor in the female reproductive tract. The aim of the present study was to immunolocalize and assess semi-quantitatively VEGF immunostaining in cells of proliferative phase (n = 3), secretory phase (n = 6) and hyperplastic (n = 6) human endometrial samples. VEGF concentrations were significantly higher in glandular (P < 0.001) and stromal (P < 0.01) compartments of proliferative stage endometrium compared with those in secretory stage and hyperplastic endometrial samples, with no difference in the scores for glandular and stromal compartments between secretory stage and hyperplastic endometrial samples. Generally, glandular expression of VEGF was higher as compared to stromal compartment. Thus, it appears that endometrial VEGF expression and concentration are enhanced by estrogen, and may be correlated with neovascularization and increased vascular permeability during late proliferative period. Additionally, there was no enhancement in VEGF expression in hyperplastic glands, suggesting that regulation of glandular growth and that of angiogenesis in human endometrium operate through different mechanisms.en_US
dc.description.affiliationDepartment of Physiology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationNaresh B, Sengupta J, Bhargava V, Kinra G, Hu J, Ghosh D. Immunohistological localisation of vascular endothelial growth factor in human endometrium. Indian Journal of Physiology and Pharmacology. 1999 Apr; 43(2): 165-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106540
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshCell Divisionen_US
dc.subject.meshEndometrial Hyperplasia --metabolismen_US
dc.subject.meshEndometrium --chemistryen_US
dc.subject.meshEndothelial Growth Factors --analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLymphokines --analysisen_US
dc.subject.meshMenstrual Cycle --metabolismen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshVascular Endothelial Growth Factor Aen_US
dc.subject.meshVascular Endothelial Growth Factorsen_US
dc.titleImmunohistological localisation of vascular endothelial growth factor in human endometrium.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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