An Observational Study Comparing the Adverse Effect Profiles of Sputnik V and Covaxin COVID-19 Vaccines in Adult General Population of Eastern India

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dc.contributor.authorBhowmick, Subhrojyotien_US
dc.contributor.authorMaitra, Subarnarekhaen_US
dc.contributor.authorPaul, Souviken_US
dc.contributor.authorAhmed, Ahsanen_US
dc.contributor.authorDas, Anupamen_US
dc.contributor.authorKundu, Tithishrien_US
dc.contributor.authorDas, Ninaen_US
dc.contributor.authorRay, Krishnangshuen_US
dc.contributor.authorPurkayastha, Sujit Karen_US
dc.date.accessioned2023-06-17T08:34:51Z
dc.date.available2023-06-17T08:34:51Z
dc.date.issued2022-08
dc.description.abstractAim : Currently no data is available on the safety profile of COVID-19 Vaccines like Covaxin and Sputnik V from Eastern India. Our aim was to evaluate the safety profiles of Covaxin and Sputnik V Vaccine in Eastern India. Methods : 0.5 ml of Covaxin and Sputnik V given to 701 adults in a two-dose regimen at a private tertiary care Hospital, Kolkata, with the doses separated by 4-7 weeks in Covaxin and 3 weeks in Sputnik V. Data regarding local and systemic Adverse Event Following Immunizations (AEFIs) was collected 30 minutes after vaccination and also on the first- and seventh-day following vaccination after each dosage. Results : Incidence of AEFI was 65% and 59% following the first dose of vaccination in Covaxin and Sputnik V groups, respectively. Incidence of AEFI was 83% and 70% after the second dose in Covaxin and Sputnik V groups. Pain in the injection site was the most common adverse effect. Body-ache, fever and tiredness were other systemic side effects. Adverse effects were noticeably more after the second dose. Over half of the reactions were mild in nature. Covaxin had a higher number of moderate adverse reactions after both doses. Adults with age >40 years, Comorbidities, Hypertension and Diabetes had a smaller number of side effects following the first dose of vaccination. People with previous COVID-19 infections had noticeably fewer adverse effects after the second dose. Allergic adults were associated with more systemic side effects, whereas Hypertensive adults had less total AEFI. Conclusion : Both Covaxin and Sputnik V had favorable safety profiles. Sputnik V vaccine had significantly fewer AEFIs compared to Covaxin. Age, co-morbidities, specifically hypertension, Diabetes, Allergy and previous history of COVID-19 infection, were important variables observed in the prevalence of side effects.en_US
dc.identifier.affiliationsMD, FISQUA (Ireland), Associate Professor, Department of Pharmacology, KPC Medical College, Kolkata 700032en_US
dc.identifier.affiliationsB Pharm, M Pharm Pharmacology Student, Department of Pharmacology, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata 700114en_US
dc.identifier.affiliationsMBBS, DA, DNB, EDIC, IFCCM, Assistant Professor, Department of Anaesthesiology, KPC Medical College, Kolkata 700032en_US
dc.identifier.affiliationsBHM, EMBA Heath care, ADTQM,LSSGB, Senior Manager, Department of Medical Administration, Peerless Hospital and B K Roy Research Center, Kolkata 700094en_US
dc.identifier.affiliationsMD, Assistant Professor, Department of Pharmacology, Manipal Tata Medical College, Jamshedpur, Manipal Academy of Higher Education, Manipal, Karnataka, India 576104 and Corresponding Authoren_US
dc.identifier.affiliationsMBBS, MD, Professor and Head, Department of Pharmacology, KPC Medical College, Kolkata 700032en_US
dc.identifier.affiliationsMD, PhD, DA, MBA, FICP, Professor, Medical Director, Peerless Hospital and B K Roy Research Center, Kolkataen_US
dc.identifier.affiliationsMD, FRCP, Senior Consultant, Department of Gastroenterology, Peerless Hospital and B K Roy Research Centre, Kolkata 700094en_US
dc.identifier.citationBhowmick Subhrojyoti, Maitra Subarnarekha, Paul Souvik, Ahmed Ahsan, Das Anupam, Kundu Tithishri, Das Nina, Ray Krishnangshu, Purkayastha Sujit Kar. An Observational Study Comparing the Adverse Effect Profiles of Sputnik V and Covaxin COVID-19 Vaccines in Adult General Population of Eastern India. Journal of The Indian Medical Association. 2022 Aug; 120(8): 40-44en_US
dc.identifier.issn0019-5847
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216595
dc.languageenen_US
dc.publisherIndian Medical Associationen_US
dc.relation.issuenumber8en_US
dc.relation.volume120en_US
dc.source.urihttps://www.onlinejima.com/read_journals.php?article=998en_US
dc.subjectCOVID-19 vaccineen_US
dc.subjectAEFIen_US
dc.subjectSafetyen_US
dc.subjectCovaxin,Sputnik Ven_US
dc.subjectAdverse effectsen_US
dc.subjectSide effectsen_US
dc.subjectIndiaen_US
dc.titleAn Observational Study Comparing the Adverse Effect Profiles of Sputnik V and Covaxin COVID-19 Vaccines in Adult General Population of Eastern Indiaen_US
dc.typeJournal Articleen_US
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