Ataxia telangiectasia: Family management.
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Date
2010-01
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Abstract
Ataxia telangiectasia (AT) is a rare autosomal recessive disease resulting in progressive degeneration of multiple systems in the body. Both A-T homozygote and heterozygote are at increased risk of developing malignancy. We report a family in which three generations were affected by this disorder. Our index case is a 12-year-old female child, born of second degree consanguineous marriage diagnosed to have ataxia telangiectasia at the age of four years, now presented with fever and neck swelling of one month duration. Family history suggestive of ataxia telangiectasia in maternal uncle and younger sibling was present. History of premature coronary artery disease and death in paternal grandfather was present. On evaluation, child was diagnosed to have Alk negative anaplastic large T cell lymphoma. Management included genetic counseling, examination of all the family members, identification of A-T homozygote and providing appropriate care, regular surveillance of the heterozygote for malignancy.
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Keywords
Ataxia Telangiectasia, family management, malignancy
Citation
Seshachalam Arun, Cyriac Sanju, Reddy Neelesh, Gnana Sagar T. Ataxia telangiectasia: Family management. Indian Journal of Human Genetics. 2010 Jan; 16(1): 39-42.