Comparative Evaluation of Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade in Patients Undergoing Cholecystectomy under General Anesthesia

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dc.contributor.authorSharma, Aen_US
dc.contributor.authorChatrath, Ven_US
dc.contributor.authorMarwah, Den_US
dc.contributor.authorKamboj, Aen_US
dc.contributor.authorGupta, Men_US
dc.contributor.authorArora, A.en_US
dc.date.accessioned2025-05-12T08:15:07Z
dc.date.available2025-05-12T08:15:07Z
dc.date.issued2024-11
dc.description.abstractBackground and Aims: Muscle relaxation is the vital element of general anesthesia. It is attained using neuromuscular blocking agents (NMBAs). After surgery, full restoration of patient’s muscle strength is essential to ensure safe post-operative recovery. The reversal of non-depolarizing NMBAs is achieved using acetylcholinesterase inhibitors or gamma-cyclodextrins. The present study was done to compare Sugammadex and neostigmine for the reversal of vecuronium-induced neuromuscular blockade in patients undergoing cholecystectomy under general anesthesia. Materials and Methods: This prospective randomized double-blinded study was conducted in Guru Nanak Dev Hospital attached to Government Medical College, Amritsar, after taking written informed consent from patients in their vernacular language and approval from the Institutional Ethics Committee. This study was conducted on 60 patients, aged 18–60 years, American Society of Anesthesiologists Grade I and II, scheduled to undergo elective cholecystectomy under general anesthesia. The patients were randomly divided into two groups with 30 patients in each group. At the end of the surgery, when train-of- four (TOF) count reached 2, Group S patients received Sugammadex 2 mg/kg intravenously, and Group N patients received neostigmine 50 mcg/kg and glycopyrrolate 10 mcg/kg combination intravenously to reverse vecuronium induced neuromuscular blockade. Results: The mean time from the study drug administration (at appearance of second twitch T2 after last dose of vecuronium) to tracheal extubation, that is, TOF ratio 0.9 was significantly faster in Sugammadex compared to neostigmine with 2.84 ± 0.592 min (mean ± standard deviation) in Group S and 14.168 ± 2.351 min in Group N. Furthermore, the mean time from study drug administration to operating room discharge ready was 8.92 ± 4.264 min in Group S, and it was 25.064 ± 10.208 min in Group N. Post-operative residual paralysis was not seen in any patient in both the groups. Conclusion: Sugammadex is faster than neostigmine-glycopyrrolate combination in reversing vecuronium-induced neuromuscular blockade. Sugammadex is safe and well tolerated. The incidence of drug-related side effects (post-operative nausea vomiting, post-operative urinary retention) was slightly lower in the Sugammadex group as compared to neostigmine group (10% and 26.6%, respectively).en_US
dc.identifier.affiliationsAssociate Professor, Department of Anaesthesiology and Critical Care, Government Medical College, Amritsar, Punjab, Indiaen_US
dc.identifier.affiliationsProfessor and Head, Department of Anaesthesiology and Critical Care, Government Medical College, Amritsar, Punjab, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Anaesthesiology and Critical Care, Government Medical College, Amritsar, Punjab, Indiaen_US
dc.identifier.affiliationsJunior Resident, Department of Anaesthesiology and Critical Care, Government Medical College, Amritsar, Punjab, Indiaen_US
dc.identifier.affiliationsIntern, Christian Medical College and Hospital, Ludhiana, Punjab, Indiaen_US
dc.identifier.affiliationsIntern, Government Medical College, Amritsar, Punjab, Indiaen_US
dc.identifier.citationSharma A, Chatrath V, Marwah D, Kamboj A, Gupta M, Arora A. . Comparative Evaluation of Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade in Patients Undergoing Cholecystectomy under General Anesthesia. International Journal of Scientific Study. 2024 Nov; 12(8): 27-31en_US
dc.identifier.issn2321-6379
dc.identifier.issn2321-595X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246952
dc.languageenen_US
dc.publisherInternational Research Organization for Life & Health Sciencesen_US
dc.relation.issuenumber8en_US
dc.relation.volume12en_US
dc.source.urihttps://www.ijss-sn.com/uploads/2/0/1/5/20153321/ijss_nov_24_oa03_-_2024.pdfen_US
dc.subjectNeostigmineen_US
dc.subjectSugammadexen_US
dc.subjectVecuronium.en_US
dc.titleComparative Evaluation of Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade in Patients Undergoing Cholecystectomy under General Anesthesiaen_US
dc.typeJournal Articleen_US
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