Hyperacute thrombolysis with IV rtPA of acute ischemic stroke: efficacy and safety profile of 54 patients at a tertiary referral center in a developing country.

Simple item page
dc.contributor.authorPadma, M Ven_US
dc.contributor.authorSingh, M Ben_US
dc.contributor.authorBhatia, Ren_US
dc.contributor.authorSrivastava, Aen_US
dc.contributor.authorTripathi, Men_US
dc.contributor.authorShukla, Gen_US
dc.contributor.authorGoyal, Ven_US
dc.contributor.authorSingh, Sen_US
dc.contributor.authorPrasad, Ken_US
dc.contributor.authorBehari, Men_US
dc.date.accessioned2007-01-03en_US
dc.date.accessioned2009-06-03T10:42:35Z
dc.date.available2007-01-03en_US
dc.date.available2009-06-03T10:42:35Z
dc.date.issued2007-01-03en_US
dc.description.abstractBACKGROUND: Given the constraints of resources, thrombolysis for acute ischemic stroke (AIS) is under evaluation in developing countries. Prothrombin time (PT), platelet count and activated partial thromboplastin time (aPTT) may not be feasible within the time window. AIM: To evaluate the safety and efficacy of thrombolysis in selected patients without the coagulation profile. DESIGN: Open, nonrandomized, observational study. MATERIALS AND METHODS: Fifty-four stroke patients were classified using TOAST criteria (large artery atherosclerotic = 13; cardioembolic = 12; small vessel occlusion = 22; other determined etiology =three; undetermined etiology = four). The mean time to reach emergency was 2.4h (1.15-3.4), the mean door to CT, 24 min (10-47) and the door to recombinant tissue plasminogen activator (r-tPA) injection, 26.8 min (25-67). The NIHSS scores ranged from 11 to 22 (mean = 15.5 +/- 2.7). Patients with history of liver or renal disease or those on anticoagulants were excluded. The PT, aPTT and platelet count were not done. Recombinant tissue plasminogen activator was administered at a dosage of 0.9 mg/Kg. RESULTS: Thirty-five patients (65%) significantly improved on NIHSS at 48 h (> or =4 points) (mean change = 10; range= 4-17). At one month, 43 (79%) improved on Barthel Index (mean change = 45%). One each developed small frontal lobe hemorrhage and recurrent stroke; one died of aspiration; and eight showed no improvement. CONCLUSIONS: Hyperacute thrombolysis was found useful and safe in selected patients with AIS even without the coagulation studies.en_US
dc.description.affiliationDepartment of Neurology, All India Institute of Medical Sciences, New Delhi - 110 029, India. vasanthapadma123@rediffmail.comen_US
dc.identifier.citationPadma MV, Singh MB, Bhatia R, Srivastava A, Tripathi M, Shukla G, Goyal V, Singh S, Prasad K, Behari M. Hyperacute thrombolysis with IV rtPA of acute ischemic stroke: efficacy and safety profile of 54 patients at a tertiary referral center in a developing country. Neurology India. 2007 Jan-Mar; 55(1): 46-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/120404
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinolytic Agents --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshStroke --drug therapyen_US
dc.subject.meshThrombolytic Therapyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTissue Plasminogen Activator --therapeutic useen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleHyperacute thrombolysis with IV rtPA of acute ischemic stroke: efficacy and safety profile of 54 patients at a tertiary referral center in a developing country.en_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Neurology India