Comparison of anti-ischemic effects of isosorbide-5-mononitrate, metoprolol and diltiazem: a study based on serial treadmill exercise test.

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dc.contributor.authorGupta, D Ken_US
dc.contributor.authorNegi, P Cen_US
dc.contributor.authorPatial, R Ken_US
dc.contributor.authorBansal, S Ken_US
dc.date.accessioned1995-09-01en_US
dc.date.accessioned2009-05-27T04:25:51Z
dc.date.available1995-09-01en_US
dc.date.available2009-05-27T04:25:51Z
dc.date.issued1995-09-01en_US
dc.description.abstractA prospective double blind cross over study compared the anti-ischemic effect of 20 mg of isosorbide-5-mononitrate (IS-5-MN), 60 mg of diltiazem and 100 mg of metoprolol by performing serial treadmill tests (TMTs) following oral administration of single dose of each drug in 28 patients of ischemic heart disease with positive exercise TMT. The anti-ischemic effect of IS-5-MN, diltiazem and metoprolol was evaluated by assessing the time to onset of ischemia (400.8 +/- 41.1 vs 394.1 +/- 36.0 vs 412.7 +/- 36.6 secs respectively, all p > or = 0.05), duration of ischemia (390.9 +/- 58.5 vs 447.6 +/- 65.9 vs 419.4 +/- 58.7 secs respectively, all p > or = 0.05), duration of exercise 464.0 +/- 32.9 vs 476.8 +/- 32.5 vs 502.6 +/- 31.3 secs respectively, all p > or = 0.05) and severity of ischemia by scoring system (10.0 +/- 1.5 vs 10.7 +/- 1.4 vs 9.8 +/- 1.5 respectively, all p > or = 0.05). Thus, the present study suggests that there is no significant difference in the anti-ischemic effect of IS-5-MN, diltiazem and metoprolol and also suggests that the anti-ischemic effect of metoprolol is primarily by decreasing the heart rate while IS-5-MN and diltiazem exert anti-ischemic effect probably by decreasing oxygen demand and improving coronary blood flow.en_US
dc.description.affiliationIndira Gandhi Medical College, Shimla.en_US
dc.identifier.citationGupta DK, Negi PC, Patial RK, Bansal SK. Comparison of anti-ischemic effects of isosorbide-5-mononitrate, metoprolol and diltiazem: a study based on serial treadmill exercise test. Indian Heart Journal. 1995 Sep-Oct; 47(5): 485-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/5096
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdrenergic beta-Antagonists --therapeutic useen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCross-Over Studiesen_US
dc.subject.meshDiltiazem --therapeutic useen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshExercise Testen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIsosorbide Dinitrate --analogs & derivativesen_US
dc.subject.meshMaleen_US
dc.subject.meshMetoprolol --therapeutic useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Ischemia --drug therapyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshVasodilator Agents --therapeutic useen_US
dc.titleComparison of anti-ischemic effects of isosorbide-5-mononitrate, metoprolol and diltiazem: a study based on serial treadmill exercise test.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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