Curcumin as a therapeutic agent against cancer.
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Date
2007-10
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Abstract
Background: Curcumin is an important chemopreventive agent against cancer. Recently, it has been reported
that curcumin has also anti-angiogenic effects in tumor.
Objective: This article reviews the effect of curcumin against tumor angiogenesis from view-points of cancer
microcirculation and biomarkers.
Results and conclusion. We demonstrated an anti-angiogenic effect of curcumin in tumors using nude mice. We
studied the inhibitory effects of curcumin on tumor-induced neocapillaries and proangiogenic factors, based on
our intravital fluorescent observation. Finally, we hypothesized a possible mechanism for curcumin effect in
tumor.
Description
Keywords
Anti-angiogenic effect, biomarker, cancer, curcumin, microcirculation, neocapillaries, nude mice
Citation
Asian Biomedicine (Research Reviews and News); Vol. 1 No. 3 Oct 2007; 239-252.