Prevalence of ZAP-70 and CD 38 in Indian chronic lymphocytic leukemia patients.

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dc.contributor.authorGogia, A
dc.contributor.authorSharma, A
dc.contributor.authorRaina, V
dc.contributor.authorKumar, L
dc.contributor.authorGupta, R
dc.contributor.authorKumar, R
dc.date.accessioned2014-12-30T05:47:28Z
dc.date.available2014-12-30T05:47:28Z
dc.date.issued2013-10
dc.description.abstractAim of Study: Chronic lymphocytic leukemia (CLL) is the most common chronic lympho-proliferative disorder. This study was undertaken to know the prevalence of ZAP-70 and CD 38 in the treatment naive patients of CLL seen at a tertiary care centre of north India. Materials and Methods: ZAP-70 and CD 38 were tested by flow cytometry on peripheral blood samples. ZAP-70 positive and CD 38 positivity was defined as positive expression on 20% and 30% of CLL cells, respectively. Clinico-hematological profile and its correlation with ZAP-70 and CD 38 were assessed in consecutive 80 CLL patients. Results: There were 64 males and median age of the group was 58 years. Sixteen patients (20%) were asymptomatic and diagnosed incidentally. Median total lymphocyte count (TLC) at presentation was 62 × 10 9 /L. Rai stage distribution was: Stage 0-6, stage I-20, stage II-36, stage III-5, and stage IV-13. ZAP-70 and CD 38 positivity were detected in 20 patients (25%) and 29 patients (36%), respectively. Eleven patients were positive and 34 were negative for both ZAP-70 and CD 38 yielding a concordance rate of 56%. There was no statistically significant difference between ZAP-70 and CD 38 positivity and negativity with regard to age, sex, Lymphocyte count, lymphadenopathy, organomegaly, and Rai staging. Conclusion: ZAP-70 and CD 38 positivity were detected 25% and 36%, respectively, with concordance rate of 56%, which is higher than Western literature. There was no correlation of ZAP-70 and CD 38 positivity with age, sex, lymphadenopathy, organomegaly, and Rai staging.en_US
dc.identifier.citationGogia A, Sharma A, Raina V, Kumar L, Gupta R, Kumar R. Prevalence of ZAP-70 and CD 38 in Indian chronic lymphocytic leukemia patients. Indian Journal of Cancer. 2013 Oct-Dec; 50(4): 333-336.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/154308
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2013;volume=50;issue=4;spage=333;epage=336;aulast=Gogiaen_US
dc.subjectCD38en_US
dc.subjectchronic lymphocytic leukemiaen_US
dc.subjectZAP-70en_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAntigens, CD38
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell --epidemiology
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell --immunology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPrevalence
dc.subject.meshZAP-70 Protein-Tyrosine Kinase
dc.titlePrevalence of ZAP-70 and CD 38 in Indian chronic lymphocytic leukemia patients.en_US
dc.typeArticleen_US
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