Comparative analysis of camelid mitochondrial genomes

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dc.contributor.authorManee, Manee M.en_US
dc.contributor.authorALSHEHRI, Manal A.en_US
dc.contributor.authorBINGHADIR, Sarah A.en_US
dc.contributor.authorALDHAFER, Shahad H.en_US
dc.contributor.authorALSWAILEM, Riyof M.en_US
dc.contributor.authorALGARNI, Abdulmalek T.en_US
dc.contributor.authorAL-SHOMRANI, Badr M.en_US
dc.contributor.authorAL-FAGEEH, Mohamed B.en_US
dc.date.accessioned2020-11-18T10:20:47Z
dc.date.available2020-11-18T10:20:47Z
dc.date.issued2019-08
dc.description.abstractCamelus dromedarius has played a pivotal role in both culture and way of life in the Arabian peninsula, particularly in arid regions where other domestic animals cannot be easily domesticated. Although, the mitochondrial genomes have recently been sequenced for several camelid species, wider phylogenetic studies are yet to be performed. The features of conserved gene elements, rapid evolutionary rate, and rare recombination make the mitochondrial genome a useful molecular marker for phylogenetic studies of closely related species. Here we carried out a comparative analysis of previously sequenced mitochondrial genomes of camelids with an emphasis on C. dromedarius, revealing a number of noticeable findings. First, the arrangement of mitochondrial genes in C. dromedarius is similar to those of the other camelids. Second, multiple sequence alignment of intergenic regions shows up to 90% similarity across different kinds of camels, with dromedary camels to reach 99%. Third, we successfully identified the three domains (termination-associated sequence, conserved domain and conserved sequence block) of the control region structure. The phylogenetic tree analysis showed that C. dromedarius mitogenomes were significantly clustered in the same clade with Lama pacos mitogenome. These findings will enhance our understanding of the nucleotide composition and molecular evolution of the mitogenomes of the genus Camelus, and provide more data for comparative mitogenomics in the family Camelidae.en_US
dc.identifier.affiliationsNational Centre for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabiaen_US
dc.identifier.affiliationsCentre of Excellence for Genomics, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabiaen_US
dc.identifier.affiliationsCollege of Computer and Information Sciences, Imam Muhammad Ibn Saud Islamic University, Riyadh 11432, Saudi Arabiaen_US
dc.identifier.citationManee Manee M., Alshehri Manal A., Binghadir Sarah A., Aldhafer Shahad H., Alswailem Riyof M., Algarni Abdulmalek T., Al-Shomrani Badr M., Al-Fageeh Mohamed B.. Comparative analysis of camelid mitochondrial genomes. Journal of Genetics. 2019 Aug; 98: 1-12en_US
dc.identifier.issn0022-1333
dc.identifier.issn0973-7731
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215404
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.volume98en_US
dc.source.urihttps://doi.org/10.1007/s12041-019-1134-xen_US
dc.subjectmitochondrial DNAen_US
dc.subjectgenome annotationen_US
dc.subjectphylogenetic analysisen_US
dc.subjectcontrol regionen_US
dc.subjectintergenic regionsen_US
dc.subjectCamelus dromedarius.en_US
dc.titleComparative analysis of camelid mitochondrial genomesen_US
dc.typeJournal Articleen_US
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