Thailand diabetes registry project: prevalence of diabetic retinopathy and associated factors in type 1 diabetes mellitus.

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dc.contributor.authorChetthakul, Thanyaen_US
dc.contributor.authorLikitmaskul, Supawadeeen_US
dc.contributor.authorPlengvidhya, Nattacheten_US
dc.contributor.authorSuwanwalaikorn, Sompongseen_US
dc.contributor.authorKosachunhanun, Natapongen_US
dc.contributor.authorDeerochanawong, Chaicharnen_US
dc.contributor.authorKrittiyawong, Sirinateen_US
dc.contributor.authorLeelawatana, Rattanaen_US
dc.contributor.authorBenjasuratwong, Yupinen_US
dc.contributor.authorBunnag, Pongamornen_US
dc.contributor.authorPrathipanawatr, Thongchaien_US
dc.contributor.authorNgarmukos, Chardpraornen_US
dc.contributor.authorMongkolsomlit, Sirimaen_US
dc.contributor.authorRawdaree, Petchen_US
dc.date.accessioned2009-05-27T21:34:02Z
dc.date.available2009-05-27T21:34:02Z
dc.date.issued2006-08-25en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To determine the prevalence and factors associated with Diabetic Retinopathy (DR) of type 1 diabetes mellitus in Thailand. MATERIAL AND METHOD: A cross-sectional, multicenter hospital-based study was carried out from April to December 2003. Diabetic patients in diabetic clinics of 11 tertiary centers were registered. Retinopathy was evaluated by the ophthalmologists. RESULTS: Seven thousand one hundred and ni neteen diabetic patients received retinal examination. The number of patients with type 1 diabetes was 347. The prevalence of DR in type 1 diabetes was 21.6% (75). This consisted of Non-Proliferative DR (NPDR) 10.9% (38) and Proliferative DR (PDR) 10.7%. Patients with DR were significantly older, predominantly female, longer duration ofdiabetes, had higher BMI, systolic Blood Pressure (BP), diastolic BP serum creatinine, and TriGlycerides (TG) levels than those without DR. Both groups ofpatients were not different in term ofplasma glucose and glycosylated hemoglobin levels. Although the patients with DR had a higher percentage of overt proteinuria than those without DR, there was no difference in percentage of patients with positive microalbuminuria in both groups. This may be explained by limitation of data (only 16% had results of microalbuminuria and 19% had results of proteinuria). After adjusted for duration of diabetes, serum creatinine and smoking status, factors (adjusted odds ratio [95% confidence interval]) associated with DR were duration of diabetes 5-9.9 years (4.0 [1.49-10.91]), 10-14.9 years (6.86 [2.45-19.20]), 15-19.9 years (21.13 [7.22-61.78]), > or =20 years (22.15 [7.32-66.99]) when compared with duration of diabetes less than 5 years, serum creatinine >2 mg/dl (6.0 [2.09-17.22]) when compared with creatinine less than 2 mg/dl. From the presented model, age, gender, systolic BP >140 mmHg, diastolic BP >90 mmHg, serum TG and smoking status were not factors associated with DR. CONCLUSION: Diabetic retinopathy affects about one fifth of type 1 diabetic patients in our study. The authors found the factors associated with DR in type 1 DM were duration of diabetes and serum creatinine. Regular screening for DR and more aggressive management of metabolic factors should be done to reduce the prevalence ofDR.en_US
dc.description.affiliationDepartment of Medicine, Maharat Nakhon Ratchasima Hospital, Thailand. thanyachet@yahoo.comen_US
dc.identifier.citationChetthakul T, Likitmaskul S, Plengvidhya N, Suwanwalaikorn S, Kosachunhanun N, Deerochanawong C, Krittiyawong S, Leelawatana R, Benjasuratwong Y, Bunnag P, Prathipanawatr T, Ngarmukos C, Mongkolsomlit S, Rawdaree P. Thailand diabetes registry project: prevalence of diabetic retinopathy and associated factors in type 1 diabetes mellitus. Journal of the Medical Association of Thailand. 2006 Aug; 89 Suppl 1(): S17-26en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45014
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCreatinine --blooden_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDiabetes Complicationsen_US
dc.subject.meshDiabetes Mellitus, Type 1 --physiopathologyen_US
dc.subject.meshDiabetic Retinopathy --epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRegistriesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThailand --epidemiologyen_US
dc.titleThailand diabetes registry project: prevalence of diabetic retinopathy and associated factors in type 1 diabetes mellitus.en_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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