Antimicrobial resistance in Enterococcus faecalis at a tertiary care centre of northern India.

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dc.contributor.authorMathur, Purvaen_US
dc.contributor.authorKapil, Artien_US
dc.contributor.authorChandra, Rachnaen_US
dc.contributor.authorSharma, Pratibhaen_US
dc.contributor.authorDas, Bimalen_US
dc.date.accessioned2003-07-30en_US
dc.date.accessioned2009-05-27T07:57:46Z
dc.date.available2003-07-30en_US
dc.date.available2009-05-27T07:57:46Z
dc.date.issued2003-07-30en_US
dc.description.abstractBACKGROUND & OBJECTIVES: Multiresistant enterococci are emerging as a leading nosocomial pathogen. Knowledge of the profile of antimicrobial resistance is essential to formulate treatment guidelines for infections caused by enterococci. This study reports the antimicrobial sensitivity of enterococci isolated during a one year period from clinical samples of patients admitted to a teriary care hospital of Delhi. METHODS: A total of 444 isolates of Enterococcus faecalis were screened for antimicrobial susceptibility by the disk diffusion technique as recommended by the National Committee for Clinical Laboratory Standards (NCCLS). Screening for vancomycin resistance was done by the vancomycin screen agar method recommended by NCCLS, which was confirmed by determination of minimum inhibitory concentration (MIC) using microbroth dilution and E-test methods. Vancomycin resistance phenotypes were determined by polymerase chain reaction. RESULTS: A total of 115 (26%) isolates had high level aminoglycoside resistance, 293 (66%) were resistant to ampicillin, 391 (88%) to ciprofloxacin and 377 (85%) to erythromycin. Vancomycin resistance was found in five (1%) isolates, of which four had van A phenotype and one had van B phenotype. INTERPRETATION & CONCLUSION: Emergence of vancomycin resistant enterococci is of concern due to the limited therapeutic options. Implementation of infection control measures can contain the spread of these resistant bacteria.en_US
dc.description.affiliationDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.en_US
dc.identifier.citationMathur P, Kapil A, Chandra R, Sharma P, Das B. Antimicrobial resistance in Enterococcus faecalis at a tertiary care centre of northern India. Indian Journal of Medical Research. 2003 Jul; 118(): 25-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/22729
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshDNA, Bacterial --geneticsen_US
dc.subject.meshDrug Resistance, Bacterialen_US
dc.subject.meshDrug Resistance, Multiple, Bacterialen_US
dc.subject.meshEnterococcus faecalis --drug effectsen_US
dc.subject.meshGram-Positive Bacterial Infections --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshVancomycin Resistance --geneticsen_US
dc.titleAntimicrobial resistance in Enterococcus faecalis at a tertiary care centre of northern India.en_US
dc.typeJournal Articleen_US
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