Alterations in Thyroid Hormone Levels in Children with Protein-Energy Malnutrition

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dc.contributor.authorOinam, PDen_US
dc.contributor.authorTakhelmayum, PSen_US
dc.contributor.authorWahengbam, DDen_US
dc.contributor.authorMoirangthem, Men_US
dc.contributor.authorMaisnam, ASen_US
dc.date.accessioned2025-08-13T09:54:22Z
dc.date.available2025-08-13T09:54:22Z
dc.date.issued2025-06
dc.description.abstractBackground: Nutritional deficiencies are among the most significant public health challenges in India and other developing nations. Among those nutritional diseases, the Protein Energy Malnutrition (PEM) is the most prevalent one, affecting a large population especially children under five and is a major cause of morbidity and mortality. Aims and Objectives: To estimate serum total thyroxine (TT4), total tri-iodothyronine (TT3), thyroid stimulating hormones (TSH) in normal controls and children with PEM. To find out relationship between thyroid hormones and different grades of PEM. Methodology: Fifty children below 12 years of age suffering from different grades of protein energy malnutrition admitted in Pediatric ward, RIMS, Imphal, were selected as cases. Fifty healthy children, closely matched for age and gender, formed the control group. The study was carried out over a 24-month period, beginning in September 2016 and concluding in August 2018. Total thyroxine (TT4) and total trio-iodothyronine (TT3) were estimated by ELISA. Results: Serum thyroid hormones (TT3, TT4 and TSH) were significantly decreased in PEM when compared with controls. Among the different grades of PEM, total tri-iodothyronine (TT3) level was significantly low in Marasmic kwashiorkor children (0.61±0.14) whereas undernutrition group has the lowest value of Total Thyroxine (5.31±0.65) and TSH (1.60±0.81). Conclusion: A decrease in circulating thyroid hormone levels was linked to the severity of PEM. All the PEM cases should undergo a screening for thyroid hormone status which is essential for proper growth and health of the children.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Shija Academy of Health Sciences, Imphal, Manipur, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Shija Academy of Health Sciences, Imphal, Manipur, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Shija Academy of Health Sciences, Imphal, Manipur, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Shija Academy of Health Sciences, Imphal, Manipur, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Shija Academy of Health Sciences, Imphal, Manipur, Indiaen_US
dc.identifier.citationOinam PD, Takhelmayum PS, Wahengbam DD, Moirangthem M, Maisnam AS. Alterations in Thyroid Hormone Levels in Children with Protein-Energy Malnutrition. National Journal of Medical Research . 2025 Jun; 15(2): 92-95en_US
dc.identifier.issn2249-4995
dc.identifier.issn2277-8810
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252782
dc.languageenen_US
dc.publisherMedsci Publicationsen_US
dc.relation.issuenumber2en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.55489/njmr.150220251051en_US
dc.subjectProtein energy malnutritionen_US
dc.subjectThyroid hormonesen_US
dc.subjectMarasmusen_US
dc.subjectKwashiorkoren_US
dc.titleAlterations in Thyroid Hormone Levels in Children with Protein-Energy Malnutritionen_US
dc.typeJournal Articleen_US
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