Comparison of Perioperative Bleeding in Transurethral Resection of Prostate for Benign Prostatic Hyperplasia with and without Preoperative Dutasteride

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dc.contributor.authorTiwari, Joneshen_US
dc.contributor.authorBK, Mukeshen_US
dc.contributor.authorBhatta, Om Prakashen_US
dc.contributor.authorDaha, Sunil Kumaren_US
dc.date.accessioned2025-05-09T11:04:41Z
dc.date.available2025-05-09T11:04:41Z
dc.date.issued2024-06
dc.description.abstractIntroduction: Benign Prostate Hyperplasia (BPH) is characterized by increased proliferation of stromal and acinar cells around the urethra, prolonged by increased gland angiogenesis. The increased vascularity can result in massive bleeding during and after TURP. 5 alpha-reductase inhibitor treatment has been reported to reduce this bleeding. There is conflict regarding use of Dutasteride before surgery to decrease intraoperative blood loss. This study aims to compare the perioperative bleeding in TURP with and without two weeks of preoperative treatment with dutasteride in patients with BPH. Material and Methods: This is a Single-center, Randomized Controlled Open-label Trial done at Department of Urology and Renal Transplant Unit-II, Mayo Hospital Lahore, Pakistan, from February 17, 2018, to February 17, 2019. Patients fulfilling the inclusion criteria of age over 55, unresponsive to medical therapy, and an enlarged prostate (40-70 grams) with an absolute indication for surgery. Group A received a tablet of dutasteride 0.5 mg once a day. Group B did not receive dutasteride two weeks before transurethral resection of the prostate for BPH. Patients were followed up after 24 hours of surgery in which hematocrit levels were estimated. Blood loss was calculated by recording pre-operative and post-operative (after 24 hours) hematocrit levels. Results: 64 patients were randomized into two groups, i.e., Group A (TURP with dutasteride) and Group B (TURP without dutasteride). The mean age was 66.4�5 years in group A and 66.5�2 years in group B. The mean blood loss was 158.3�1.1 ml in group a patients and 311.5�0.7 ml in group B, with a p-value of 0.000054, which is statistically significant. Conclusions: Patients on dutasteride have less perioperative bleeding during transurethral resection of the prostate for BPH than controls.en_US
dc.identifier.affiliationsConsultant, Seti provincial hospital, Nepalen_US
dc.identifier.affiliationsMedical officer, Seti provincial hospital, Nepalen_US
dc.identifier.affiliationsMedical officer, Nova Hospital, Dhangadhien_US
dc.identifier.affiliationsMedical officer, Bardibas Hospitalen_US
dc.identifier.citationTiwari Jonesh, BK Mukesh, Bhatta Om Prakash, Daha Sunil Kumar. Comparison of Perioperative Bleeding in Transurethral Resection of Prostate for Benign Prostatic Hyperplasia with and without Preoperative Dutasteride. International Journal of Contemporary Medical Research. 2024 Jun; 11(6): 1-5en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246165
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber6en_US
dc.relation.volume11en_US
dc.source.urihttps://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_3737.pdfen_US
dc.subjectTransurethral Resection of Prostateen_US
dc.subjectDutasterideen_US
dc.subjectBenign Prostatic Hyperplasiaen_US
dc.titleComparison of Perioperative Bleeding in Transurethral Resection of Prostate for Benign Prostatic Hyperplasia with and without Preoperative Dutasterideen_US
dc.typeJournal Articleen_US
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