Potency assay of antivenom: neutralisation of biological properties of three Russell's viper venoms by a monospecific antivenom
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1994-12-01
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Abstract
Potency assay of a monovalent Russell's viper antivenom manufactured by Myanmar Pharmaceutical Factory (MPF) batch DN 866088 exp. 4/92 was assessed with Russell's viper venoms of Tharyarwady, Kungyankone and Daedaye in rodents using WHO standard tests of neutralising activity. There is variation in the amount of antivenom requires to neutralise individual biological property of three venoms and it is noteworthy that 4 times greater amount of antivenom is needed to neutralise haemorrhagic activity of Tharyarwady and defibrinogenating activenom of Kungyankone than the other two venoms. This variable performance of antivenom may be responsible for failure of correction of some venom induced effects seen in Russell's viper bite cases. It is suggested that a wider range of standard assays should be included in characterising the potency of antivenom.
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Tun Pe, Aye Aye Myint, Kyi May Htwe. Potency assay of antivenom: neutralisation of biological properties of three Russell's viper venoms by a monospecific antivenom. Myanmar Health Sciences Research Journal. 1994; 6(3): 118-120