Spectrum of histological features in non-alcoholic fatty liver disease.

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dc.contributor.authorVasdev, Nandinien_US
dc.contributor.authorKakati, Anjali Gen_US
dc.contributor.authorSaigal, Sanjiven_US
dc.contributor.authorNayak, Nabeen Cen_US
dc.date.accessioned2007-11-14en_US
dc.date.accessioned2009-06-03T06:37:58Z
dc.date.available2007-11-14en_US
dc.date.available2009-06-03T06:37:58Z
dc.date.issued2007-11-14en_US
dc.description.abstractBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has become an Important entity globally, including in India and other Asian countries. Morphological evaluation of a liver biopsy is necessary for the diagnosis, staging and possibly management of this disease. However, the spectrum of changes in the liver, their evolution, Interrelationships and implications are incompletely understood. We aimed to study the spectrum of histological abnormalities in NAFLD. METHODS: The study material was drawn from a pool of 80 liver biopsies diagnosed in our laboratory as NAFLD, 67 retrieved retrospectively from our records and 13 obtained prospectively with complete clinical data. After comprehensive histological assessment, a detailed analysis was done of 32 of those categorized as definitive NAFLD on the basis of a dependable history of no alcohol Intake and seronegativity for hepatitis virus B and C Infections. RESULTS: Fatty change was preferentially seen in acinar zones 2 and 3, more so in the former. Steatotic cells varied in size; some large ones were non-spherical. Steatosis alone was present in more than a quarter of the cases and steatosis along with inflammation was present in half. The magnitude of steatosis correlated with inflammation, while both these seemed to correlate with hepatocyte Injury and fibrosis. CONCLUSION: A proportion of patients with NAFLD show only hepatic steatosis. An Increasing grade of steatosis is associated with greater Inflammation, hepatocyte injury and acinar fibrosis. Preferential involvement of acinar zone 2 by steatosis, the morphology of the steatotic cells, and nature and location of inflammation are important in the diagnosis of NAFLD and its differentiation from other causes of fatty liver.en_US
dc.description.affiliationDepartment of Histopathology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, India. minivasdev@rediffmail.comen_US
dc.identifier.citationVasdev N, Kakati AG, Saigal S, Nayak NC. Spectrum of histological features in non-alcoholic fatty liver disease. National Medical Journal of India. 2007 Nov-Dec; 20(6): 282-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/119175
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBiopsyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshFatty Liver --diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B --pathologyen_US
dc.subject.meshHepatitis C --pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInflammationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.titleSpectrum of histological features in non-alcoholic fatty liver disease.en_US
dc.typeJournal Articleen_US
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