Management of Changes in Liver Chemistry in Male Rats Acutely Exposed to Crude Petroleum Oil.

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dc.contributor.authorUjowundu, C O
dc.contributor.authorKalu, F N
dc.contributor.authorNwaogu, L A
dc.contributor.authorEzeji, E U
dc.contributor.authorIgwe, K O
dc.date.accessioned2014-05-23T12:01:48Z
dc.date.available2014-05-23T12:01:48Z
dc.date.issued2012-06
dc.description.abstractThis Study investigated the protective effect of Gongronema latifolium supplemented diet against acute hepatotoxicity induced by crude petroleum oil on male rats. Oral exposure of rats to crude petroleum significantly decreased (P<0.05) the activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD). Significant decrease in concentrations of glutathione and increase in malondialdehyde (MDA) was observed also, but catalase activity decreased nonsignificantly. Activities of these oxidative stress enzymes and concentrations of glutathione and MDA in rats exposed to crude petroleum and fed simultaneously with 20% G. latifolium supplemented diet were close to those obtained in control rats. Fluctuations in liver function parameters and serum lipid profile were observed. These results indicate that consumption of G. latifolium supplemented diet has protective effect against crude oil induced liver tissue damage.en_US
dc.identifier.citationUjowundu C O, Kalu F N, Nwaogu L A, Ezeji E U, Igwe K O. Management of Changes in Liver Chemistry in Male Rats Acutely Exposed to Crude Petroleum Oil. Journal of Applied Pharmaceutical Science. 2012 June; 2(6): 116-120.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/151265
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=514en_US
dc.subjectHepatotoxicityen_US
dc.subjectoxidative enzymesen_US
dc.subjectcrude oilen_US
dc.subjectliver function enzymesen_US
dc.subjectGongronema latifoliumen_US
dc.titleManagement of Changes in Liver Chemistry in Male Rats Acutely Exposed to Crude Petroleum Oil.en_US
dc.typeArticleen_US
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