Rapid diagnosis of disseminated Mycobacterium avium complex infection mimicking metastatic malignancy using metagenomic next-generation sequencing

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dc.contributor.authorLiu, Yen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorPu, Yen_US
dc.contributor.authorTang, S.en_US
dc.date.accessioned2025-08-13T09:59:10Z
dc.date.available2025-08-13T09:59:10Z
dc.date.issued2025-02
dc.description.abstractDisseminated non-tuberculous mycobacteria (NTM) disease, which is mainly found in immunocompromised individuals, is a rare and severe infection whose diagnosis poses a challenge to clinicians. We present a patient with disseminated NTM infection mistaken for metastatic malignancy in an otherwise healthy patient and the tortuous diagnostic process. Metagenomic next-generation sequencing (mNGS) played a critical role in the diagnosis. Further screening for anti-interferon-? antibodies revealed that the patient had a potential immunodeficiency.en_US
dc.identifier.affiliationsDepartment of Infectious Diseases Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China; Department of Infectious Diseases Taicang Affiliated Hospital of Soochow University, The First People抯 Hospital of Taicang, Suzhou, Jiangsu 215400, Chinaen_US
dc.identifier.affiliationsDepartment of Infectious Diseases Taicang Affiliated Hospital of Soochow University, The First People抯 Hospital of Taicang, Suzhou, Jiangsu 215400, Chinaen_US
dc.identifier.affiliationsBeijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital, Capital Medical University, Beijing, 101149, Chinaen_US
dc.identifier.affiliationsDepartment of Infectious Diseases Taicang Affiliated Hospital of Soochow University, The First People抯 Hospital of Taicang, Suzhou, Jiangsu 215400, Chinaen_US
dc.identifier.citationLiu Y, Wang J, Pu Y, Tang S.. Rapid diagnosis of disseminated Mycobacterium avium complex infection mimicking metastatic malignancy using metagenomic next-generation sequencing. National Medical Journal of India. 2025 Feb; 38(1): 16-17en_US
dc.identifier.issn0970-258X
dc.identifier.issn2583-150X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252868
dc.languageenen_US
dc.publisherAll India Institute of Medical Sciencesen_US
dc.relation.issuenumber1en_US
dc.relation.volume38en_US
dc.source.urihttps://doi.org/10.25259/NMJI_872_2022en_US
dc.titleRapid diagnosis of disseminated Mycobacterium avium complex infection mimicking metastatic malignancy using metagenomic next-generation sequencingen_US
dc.typeJournal Articleen_US
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