Oral itraconazole in treatment of candidemia in a pediatric intensive care unit.

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dc.contributor.authorSinghi, Sunit Cen_US
dc.contributor.authorReddy, Thimmapuram C Sen_US
dc.contributor.authorChakrabarti, Arunalokeen_US
dc.date.accessioned2004-11-02en_US
dc.date.accessioned2009-05-30T14:24:49Z
dc.date.available2004-11-02en_US
dc.date.available2009-05-30T14:24:49Z
dc.date.issued2004-11-02en_US
dc.description.abstractOBJECTIVE: To examine efficacy of itraconazole in the treatment of candidemia in critically ill children. METHODS: We studied retrospectively cases of candidemia seen consecutively in our Pediatric Intensive Care Unit (PICU) over three and half years. Candida isolates from those patients included. Candida albicans--19, C. tropicalis--31, C. guillermondii--9, C.krusei--4 and C. glabrata--1. RESULTS: Of the 64 patients, 48 (75%) had symptoms suggestive of septicemia and 16 had no symptoms suggestive of septicemia. No antifungal therapy was given to asymptomatic patients; they recovered from candidemia without development of any sequelae. Of the 48 symptomatic patients 11 died before results of fungal culture became available and antifungal therapy could be started. Thirty seven patients were treated with itraconazole (10 mg/kg/day orally or through gastric tube). Seven (18.9 %) of 37 patients died, 3 within first week of antifungal therapy. Thirty (81%) patients recovered; microbiological cure was noted on average by day 14 (range 4-30 days). The mean +/- SD duration of therapy in patients who responded was 24 +/-7 days (range 21-42 days). None had any major side effect. CONCLUSION: We conclude that oral itraconazole may be effective in treatment of candidemia in children in a PICU where non-C. albicans candida species constituted majority (70%) of all Candida isolates.en_US
dc.description.affiliationDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160-012, India. drsinghi@glide.net.inen_US
dc.identifier.citationSinghi SC, Reddy TC, Chakrabarti A. Oral itraconazole in treatment of candidemia in a pediatric intensive care unit. Indian Journal of Pediatrics. 2004 Nov; 71(11): 973-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/82632
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAntifungal Agents --administration & dosageen_US
dc.subject.meshCandida --isolation & purificationen_US
dc.subject.meshCandidiasis --diagnosisen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCritical Illnessen_US
dc.subject.meshCross Infection --diagnosisen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshFungemia --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfanten_US
dc.subject.meshIntensive Care Units, Pediatricen_US
dc.subject.meshItraconazole --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshProbabilityen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleOral itraconazole in treatment of candidemia in a pediatric intensive care unit.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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