Helicobacter Pylori Eradication Therapy in both Erosive and Non-erosive Gastritis — A Prospective Study.
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Date
2014-01
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Abstract
Background: Infection with Helicobacter pylori (H. pylori) is a recognized cause of peptic
ulcer and gastritis. Persistence of infection is a definite risk factor for gastric malignancy.
Healing of gastritis after eradication of H. pylori reduces the risks of peptic ulcer disease and
gastric malignancy. Objectives: To find out the relationship of H. pylori with erosive and nonerosive
gastritis, the effect of anti-H. pylori therapy and to compare the effects of anti-H. pylori
therapy between two types of gastritis. Materials and Methods: This prospective study was
done in the Gastroenterology department of Bangabandhu Sheikh Mujib Medical University,
Dhaka from June 2008 to May 2009. One hundred eighty dyspeptic patients were enrolled for
the study. Patients with gastritis diagnosed by endoscopy underwent rapid urease test (RUT).
RUT positive patients were considered to have H. pylori infection and were treated with triple
therapy (omeprazole, amoxycillin and metronidiazole) for 14 days. Treatment responses were
assessed by clinical history and also by endoscopic biopsy and RUT. Results of endoscopic
findings and RUT after treatment were compared with pretreatment status. Results: Seventy
patients completed the treatment and finally could be assessed. Endoscopic findings of 70
patients revealed that 56 (80%) patients had erosive gastritis and 14 (20%) patients had nonerosive
gastritis. After treatment, 47 (67.1%) lesions became normal, 16 (22.9%) remained
erosive and 7 (10%) non-erosive as before. Out of 14 non-erosive diseases, 7 became normal,
while out of 56 erosive diseases 40 became normal. The erosive group responded significantly
better than the non-erosive group (c2=32.766, p<0.001). Fifty nine (84.3%) patients with
gastritis showed negative urease test after treatment. Conclusion: Strong relation between H.
pylori infection and gastritis was found. Majority were antral erosive gastritis. Erosive group
responded better than non-erosive group.
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Keywords
Erosive gastritis, Non-erosive gastritis, H. pylori, Rapid urease test (RUT)
Citation
Hasan Mohammad Quamrul, Shahin-ul-Islam M M, Mollick Shahidul Hasan, Perveen Irin, Raihan A S M A. Helicobacter Pylori Eradication Therapy in both Erosive and Non-erosive Gastritis — A Prospective Study. Journal of Enam Medical College. 2014 Jan; 4(1): 15-20.