To Study Endothelial Dysfunction by Brachial Artery Flow-mediated Dilatation and Its Relationship with Microalbuminuria in Hypertensive Individuals
No Thumbnail Available
Date
2025-03
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
IJCP Group
Abstract
Introduction: Hypertension remains a central pathophysiologic contributor to cardiovascular morbidity and mortality. In its earliest stage, the principal endothelial alteration is merely functional and addressed as “endothelial dysfunction”. Flow-mediated dilatation (FMD) of the brachial artery has been widely used as a noninvasive marker to vascular reactivity. Both microalbuminuria and endothelial dysfunction are expressions of an endothelial pathology; however, it is still uncertain whether they are interrelated, or if the two phenomena are caused in parallel by the cardiovascular risk burden. Aim: To study the relationship of brachial artery flow-mediated dilatation (BAFMD) with microalbuminuria in hypertensive subjects. Method: Total 120 subjects were included in the study comprising 80 hypertension cases and 40 controls. All subjects were subjected to anthropometric measurements and routine biochemical tests – hemogram, urea, serum creatinine, liver function test, lipid profile, BAFMD and urinary albumin to urinary creatinine ratio (30-300 mg/g Cr). Conclusion: Mean % FMD was lower in patients with abnormal microalbuminuria compared to normal and this was statistically verified, with p = 0.016, thereby verifying the central hypothesis of this study.
Description
Keywords
Hypertension, microalbuminuria, brachial artery flow-mediated dilatation
Citation
AHARWAR SANDEEP, A ARIF MOHAMMED. To Study Endothelial Dysfunction by Brachial Artery Flow-mediated Dilatation and Its Relationship with Microalbuminuria in Hypertensive Individuals. Indian Journal of Clinical Practice. 2025 Mar; 35(10): 13-23