Association of serum level of vitamin D and VDR polymorphism Fok1 with the risk or survival of pancreatic cancer in Egyptian population

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dc.contributor.authorMohamed, Amal Ahmeden_US
dc.contributor.authorAref, Ahmed Moustafaen_US
dc.contributor.authorTalima, Soha Men_US
dc.contributor.authorElshimy, Reham A Aen_US
dc.contributor.authorGerges, Shawkat Sen_US
dc.contributor.authorMeghed, Mohameden_US
dc.contributor.authorZahran, Fawkia Eissaen_US
dc.contributor.authorAdawy, Eman H EL-en_US
dc.contributor.authorAbd-Elsalam Sheriefen_US
dc.date.accessioned2020-01-02T06:26:56Z
dc.date.available2020-01-02T06:26:56Z
dc.date.issued2019-04
dc.description.abstractBACKGROUND AND AIMS: Pancreatic cancer (PC) is the fourth most common cause of death from cancer in Egypt. Few studies have been conducted to assess the relationship between vitamin D serum level and vitamin D receptor (VDR) polymorphisms with the survival of PC patients. This is the first study in Egypt to investigate the association of the status of vitamin D serum level and genotypic distribution of single nucleotide polymorphisms (SNP) Fok1 with the risk of developing PC and whether they could detect survival or not. PATIENTS AND METHODS: The study included a total of 47 PC cases that were histopathologically proven to have PC, and 37 controls that were attending at the same time for investigation but proved that they were all PC free. Pre-diagnostic concentrations of vitamin D and VDR polymorphism Fok1 were assessed from all participants in the study. RESULTS: There was a 1.5-fold increase in the serum level of vitamin D in PC patients when compared to non-PC subjects. Regarding VDR Fok1, polymorphism distribution in PC was CC (Wild Type) 26 (55.3%), CT 16 (34%), and TT 5 patients (10.7%). For the control group, CC was found in 24 (64.8%), CT in 12 (32.4%), and TT genotype was found only in one individual 1 (2.8%) with no statistically significant difference between the two studied groups (P 0.72). CONCLUSION: Low serum vitamin D or VDR-SNP is not a risk factor for PC in Egyptian patients. Recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer and improving overall survival should be carefully considered.en_US
dc.identifier.affiliationsDepartment of Biochemistry and Molecular Biology, National Hepatology and Tropical Medicine Research institute, Nasr City, Cairo, Egypten_US
dc.identifier.affiliationsFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th October City, Giza City, Giza, Egypten_US
dc.identifier.affiliationsDepartment of Clinical Oncology, Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine (NEMROCK), Kasr Al-Ainy School of Medicine, Cairo University, Giza City, Giza, Egypten_US
dc.identifier.affiliationsDepartment of Clinical Pathology, National Cancer Institute, Cairo University, Cairo Governorate, Mansoura City, Egypten_US
dc.identifier.affiliationsDepartment of Surgery, National Hepatology and Tropical Medicine Research institute, Nasr City, Cairo, Egypten_US
dc.identifier.affiliationsDepartment of Internal Medicine, Faculty of Medicine (Girls), Al-Azhar University, Nasr City, Cairo, Egypten_US
dc.identifier.affiliationsDepartment of Internal Medicine and Endocrinology, Faculty of Medicine, Mansoura University, Elgomhouria St., Mansoura City, Egypten_US
dc.identifier.affiliationsDepartment of Tropical Medicine, Faculty of Medicine, Tanta University, l-Gaish, Tanta Qism 2, Tanta, Gharbia Governorate, Egypten_US
dc.identifier.citationMohamed Amal Ahmed, Aref Ahmed Moustafa, Talima Soha M, Elshimy Reham A A, Gerges Shawkat S, Meghed Mohamed, Zahran Fawkia Eissa, Adawy Eman H EL-, Abd-Elsalam Sherief. Association of serum level of vitamin D and VDR polymorphism Fok1 with the risk or survival of pancreatic cancer in Egyptian population. Indian Journal of Cancer. 2018 Apr; 56(2): 130-134en_US
dc.identifier.issn0019-509X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/190284
dc.languageenen_US
dc.publisherIndian Cancer Societyen_US
dc.relation.issuenumber2en_US
dc.relation.volume56en_US
dc.source.urihttps://dx.doi.org10.4103/ijc.IJC_299_18en_US
dc.titleAssociation of serum level of vitamin D and VDR polymorphism Fok1 with the risk or survival of pancreatic cancer in Egyptian populationen_US
dc.typeJournal Articleen_US
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