A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients.

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dc.contributor.authorBunnag, Chaweewanen_US
dc.contributor.authorFuangtong, Ratanapornen_US
dc.contributor.authorPothirat, Chaicharnen_US
dc.contributor.authorPunyaratabandhu, Poren_US
dc.date.accessioned2009-05-27T17:16:45Z
dc.date.available2009-05-27T17:16:45Z
dc.date.issued2007-12-27en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractIn 9 study centers, 419 patients with asthma or COPD were randomized to receive two forms of salbutamol metered-dose-inhalers (MDIs), i.e. CFC-driven MDI, non-CFC (HFA) MDI and one salbutamol dry powder inhaler (DPI), in a multi-center, comparative, cross-over and randomized study, performed to facilitate the formulation of a strategic plan to phase out CFC MDIs. After having received all three forms of test products, the patients completed an evaluation questionnaire indicating their preferences, likelihood of treatment compliance on each product and the easiest one to use. Statistical analysis showed that the CFC MDI was significantly less irritating (p < 0.014) but lower in its overall appeal (p < 0.0001). The "most preferred form to be prescribed" was DPI at 47.5% followed by non-CFC at 32.5% and CFC MDI at 20.1%. Concerning the ease of use among the three forms of test products, 59.9% of the patients indicated "no difference". Adverse events were mild and occurred in only 8.2%. In conclusion, patients' preference and sensory perception among the three forms of inhalers were comparable except that the CFC MDI was significantly less irritating but lower in its overall appeal. DPI was the most preferred and easiest form to use but also the most expensive. Taking public health into consideration, a non-CFC MDI with a similar market price to the CFC MDI would be the obvious choice in a strategic plan to phase out CFC MDIs with the least difficulty to the consumers.en_US
dc.description.affiliationFaculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. sicbg@mahidol.ac.then_US
dc.identifier.citationBunnag C, Fuangtong R, Pothirat C, Punyaratabandhu P. A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients. Asian Pacific Journal of Allergy and Immunology. 2007 Jun-Sep; 25(2-3): 99-109en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36843
dc.language.isoengen_US
dc.subject.meshAdministration, Inhalationen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAlbuterol --administration & dosageen_US
dc.subject.meshAsthma --drug therapyen_US
dc.subject.meshChlorofluorocarbons, Methane --adverse effectsen_US
dc.subject.meshCross-Over Studiesen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMetered Dose Inhalers --adverse effectsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPulmonary Disease, Chronic Obstructive --drug therapyen_US
dc.subject.meshQuestionnairesen_US
dc.titleA comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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