Lack of association between a polymorphism of human thyrotropin receptor gene and autoimmune thyroid disease.

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dc.contributor.authorSunthornthepvarakul, Ten_US
dc.contributor.authorKitvitayasak, Sen_US
dc.contributor.authorNgowngarmaratana, Sen_US
dc.contributor.authorKonthong, Pen_US
dc.contributor.authorDeerochanawong, Cen_US
dc.contributor.authorSarinnapakorn, Ven_US
dc.contributor.authorPhongviratchai, Sen_US
dc.date.accessioned2009-05-27T20:31:20Z
dc.date.available2009-05-27T20:31:20Z
dc.date.issued1999-12-05en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractA polymorphism in codon 52 of the human thyrotropin receptor results in a proline to threonine substitution in the extracellular domain of the receptor, but the association with autoimmune thyroid disease has been uncertain and there is no report the prevalence of this polymorphism in Orientals. To investigate this polymorphism and the association with autoimmune thyroid disease, we studied 113 normal unrelated individuals, 142 autoimmune thyroid disease patients including 112 Graves' disease and 30 Hashimoto's thyroiditis in the Thai population. We screened genomic DNAs of these subjects for the presence of A253 by PCR amplification using a degenerate oligonucleotide primer which produces a Tth111 I restriction site only in the presence of A253. The variant allele was present in 5.3 per cent of normal and 3.5 per cent of autoimmune thyroid disease, 2.7 per cent of Graves' disease and 6.7 per cent of Hashimoto's thyroiditis. The allele distribution in autoimmune thyroid disease patients did not differ significantly from that observed in controls. No association was found between this TSH-R polymorphism and the occurrence of autoimmune thyroid disease.en_US
dc.description.affiliationDepartment of Medicine, Rajavithi Hospital, Thailand.en_US
dc.identifier.citationSunthornthepvarakul T, Kitvitayasak S, Ngowngarmaratana S, Konthong P, Deerochanawong C, Sarinnapakorn V, Phongviratchai S. Lack of association between a polymorphism of human thyrotropin receptor gene and autoimmune thyroid disease. Journal of the Medical Association of Thailand. 1999 Dec; 82(12): 1214-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/43150
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Group --geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGraves Disease --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptors, Thyrotropin --geneticsen_US
dc.subject.meshThailanden_US
dc.subject.meshThyroiditis, Autoimmune --geneticsen_US
dc.titleLack of association between a polymorphism of human thyrotropin receptor gene and autoimmune thyroid disease.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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