Potential role of serum homocysteine and uric acid level as a predictive marker for pre-eclampsia

dc.contributor.authorKunwar, Sarojen_US
dc.contributor.authorThakur, Rajesh Kumaren_US
dc.contributor.authorNepal, Rupaen_US
dc.contributor.authorPaudel, Lakshanen_US
dc.contributor.authorChaulaigai, Bimalen_US
dc.contributor.authorPaudel, Govinda Akelaen_US
dc.date.accessioned2020-11-18T10:10:32Z
dc.date.available2020-11-18T10:10:32Z
dc.date.issued2019-05
dc.description.abstractBackground:Hypertension is one of the common disorders during pregnancy and can cause severe health complications for both mother and developing fetus. Pre-eclampsia(PE) is a form of hypertensive disorder complicating pregnancy. This study was aimed to estimate serum uric acid and homocysteine level as a potential biomarker for prediction of preeclampsia. Methods:85 pre-eclamptic pregnant women and 50 normotensive pregnant women were recruited from department of Obstetrics and Gynecology, Star Hospital after obtaining the informed written consent. Blood samples were collected and analyzed for serum homocysteine and serum uric acid level.Results:Serum uric acid and homocysteine levels were found to be significantly higher in pre-eclamptic cases than in controls (6.5±0.7 mg/dl and 13.5±5.4 μmol/l in cases versus 4.3±0.8 mg/dl and 10.1±4.6 μmol/l in healthy controls). Maximum sensitivity and specificity of serum uric acid was obtained at a cut-off of 5.5 mg/dl (sensitivity-91% and Specificity-88%) and serum homocysteine at 10.7 μmol/l (sensitivity-67% and specificity-64%) respectively.Conclusions:At optimum cut off value serum uric acid showed highest sensitivity and specificity for diagnosis of pre-eclampsia. Thus, serum uric acid level is better predictive marker compared to serum homocysteine level for pre-eclampsia.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Modern Technical College, Sanepa-2, Lalitpur, Nepalen_US
dc.identifier.affiliationsDepartment of Microbiology, Modern Technical College, Sanepa-2, Lalitpur, Nepalen_US
dc.identifier.affiliationsDepartment of Biochemistry, Modern Technical College, Sanepa-2, Lalitpur, Nepalen_US
dc.identifier.affiliationsDepartment of Biochemistry, Modern Technical College, Sanepa-2, Lalitpur, Nepalen_US
dc.identifier.affiliationsDepartment of Physiology, Modern Technical College, Sanepa-2, Lalitpur, Nepalen_US
dc.identifier.citationKunwar Saroj, Thakur Rajesh Kumar, Nepal Rupa, Paudel Lakshan, Chaulaigai Bimal, Paudel Govinda Akela. Potential role of serum homocysteine and uric acid level as a predictive marker for pre-eclampsia. International Journal of Scientific Reports. 2019 May; 5(5): 119-124en_US
dc.identifier.issn2454-2456
dc.identifier.issn2454-2164
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213938
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber5en_US
dc.relation.volume5en_US
dc.source.urihttps://dx.doi.org//10.18203/issn.2454-2156.IntJSciRep20191858en_US
dc.subjectPre-eclampsiaen_US
dc.subjectHypertensionen_US
dc.subjectUric aciden_US
dc.subjectHomocysteineen_US
dc.titlePotential role of serum homocysteine and uric acid level as a predictive marker for pre-eclampsiaen_US
dc.typeJournal Articleen_US
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