2-Deoxy-D-glucose alters the cardio-respiratory parameters in anaesthetized rats.
Loading...
Date
2008-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
2-Deoxy-D-Glucose (2-DG), a synthetic analogue of glucose, is
used as an anticancer agent either alone or in combination with other
tumor treatment protocols. The present study was conducted to identify the
systemic effects of 2-DG on parameters of vital importance. The blood
pressure, ECG and respiratory excursions were recorded in anesthetized
adult rats. At the end (after 120 min) of experiments, the plasma glucose
and serum insulin levels were estimated. Injection of 2-DG (0.5 g/kg)
produced an immediate increase in mean arterial pressure (MAP) and
respiratory rate. The increase in MAP continued throughout the period of
observation (120 min) and the maximal increase was seen at 90 min (27%).
Whereas, the respiratory rate decreased by 17% at 15 min which decreased
further to 37% by 120 min. Heart rate also decreased after 2-DG in a timedependent
manner and 40% decrease was observed at 120 min.
Administration of 2-DG increased the plasma glucose level significantly
(30%) as compared to saline control group but did not increase the serum
insulin level. The results indicate that 2-DG alters the cardio-respiratory
parameters by mechanisms unrelated to plasma insulin activity.
Description
Keywords
glucose analogue, anticancer-drugs, cerebral ischemia/anoxia, hypoxia inducible factor 3α
Citation
Pandey R, Choudhry P K, Deshpande S B. 2-Deoxy-D-glucose alters the cardio-respiratory parameters in anaesthetized rats. Indian Journal of Physiology and Pharmacology. 2008 Jul-Sept; 52(3): 243-248.