Acquired neuromyotonia (Isaacs' syndrome): a case report with autonomic physiologic studies.

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dc.contributor.authorSukajintanakarn, Damrongviten_US
dc.contributor.authorMitrabhakdi, Erawadyen_US
dc.contributor.authorPhanthumchinda, Kammanten_US
dc.date.accessioned2009-05-27T18:48:40Z
dc.date.available2009-05-27T18:48:40Z
dc.date.issued2006-08-20en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractAcquired neuromyotonia (Isaacs' syndrome) is a rare disorder characterized by hyperexcitability of peripheral motor nerves. The cardinal features consist of myokymia, pseudomyotonia and contracture of hands and feet. The diagnosis of Isaacs' syndrome is based on the clinical features and classic electromyographic findings. Serum antibodies against Voltage-Gated Potassium Channels (VGKCs) are detected in some cases. The authors report a 17 year-old man presented with difficulty in walking, writing and respiratory discomfort for 7 months. His body weight had decreased from 120 to 70 kilograms during that period. Physical examination was remarkable for profound sweating. Muscles were in a state of contraction, action myotonia without percussion myotonia, myokymia and carpopedal spasm. Electromyography showed classical neuromyotonic and myokymic discharges. The investigations for conditions associated with Isaacs' syndrome were unrevealing. VGKCs antibody were not performed. Treatment with carbamazepine resulted in substantial improvement of the symptoms within 7 days.en_US
dc.description.affiliationDivision of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationSukajintanakarn D, Mitrabhakdi E, Phanthumchinda K. Acquired neuromyotonia (Isaacs' syndrome): a case report with autonomic physiologic studies. Journal of the Medical Association of Thailand. 2006 Aug; 89(8): 1308-12en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/39896
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAntibodies --immunologyen_US
dc.subject.meshAnticonvulsants --therapeutic useen_US
dc.subject.meshCarbamazepine --therapeutic useen_US
dc.subject.meshElectromyographyen_US
dc.subject.meshHumansen_US
dc.subject.meshIsaacs Syndrome --diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshPotassium Channels, Voltage-Gated --immunologyen_US
dc.titleAcquired neuromyotonia (Isaacs' syndrome): a case report with autonomic physiologic studies.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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